Dhoundiyal Shivang, Sharma Aditya, Alam Md Aftab
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Curr Drug Deliv. 2025;22(3):261-282. doi: 10.2174/0115672018279628231221105210.
The field of fiber technology is a dynamic and innovative domain that offers novel solutions for controlled and targeted therapeutic interventions. This abstract provides an overview of key aspects within this field, encompassing a range of techniques, applications, commercial developments, intellectual property, and regulatory considerations. The foundational introduction establishes the significance of fiber-based drug delivery systems. Electrospinning, a pivotal technique, has been explored in this paper, along with its various methods and applications. Monoaxial, coaxial, triaxial, and side-by-side electrospinning techniques each offer distinct advantages and applications. Centrifugal spinning, solution and melt blowing spinning, and pressurized gyration further contribute to the field's diversity. The review also delves into commercial advancements, highlighting marketed products that have successfully harnessed fiber technology. The role of intellectual property is acknowledged, with patents reflecting the innovative strides in fiber-based drug delivery. The regulatory perspective, essential for ensuring safety and efficacy, is discussed in the context of global regulatory agencies' evaluations. This review encapsulates the multidimensional nature of fiber technology in drug delivery and pharmaceuticals, showcasing its potential to revolutionize medical treatments and underscores the importance of continued collaboration between researchers, industry, and regulators for its advancement.
纤维技术领域是一个充满活力和创新性的领域，它为可控和靶向治疗干预提供了新颖的解决方案。本摘要概述了该领域的关键方面，涵盖了一系列技术、应用、商业发展、知识产权和监管考量。基础介绍确立了基于纤维的药物递送系统的重要性。本文探讨了静电纺丝这一关键技术及其各种方法和应用。单轴、同轴、三轴和并列静电纺丝技术各有独特优势和应用。离心纺丝、溶液和熔体吹塑纺丝以及加压旋转进一步丰富了该领域的多样性。该综述还深入探讨了商业进展，突出了成功利用纤维技术的上市产品。知识产权的作用得到认可，专利反映了基于纤维的药物递送方面的创新进展。在全球监管机构评估的背景下，讨论了确保安全性和有效性所必需的监管视角。本综述概括了纤维技术在药物递送和制药领域的多维度性质，展示了其变革医学治疗的潜力，并强调了研究人员、行业和监管机构之间持续合作对其发展的重要性。
