Durmuş Kasım, Turgut Nergiz Hacer, Doğan Mehtap, Tuncer Ersin, Özer Hatice, Altuntaş Emine Elif, Akyol Melih
Department of Otolaryngology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Department of Pharmacology, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey.
Adv Clin Exp Med. 2017 Oct;26(7):1063-1067. doi: 10.17219/acem/65477.
Mandibular fractures are the most common facial fractures. They can be treated by conservative techniques or by surgery. The authors hypothesized that the application of a single local dose of strontium chloride would accelerate the healing of subcondylar mandibular fractures, shorten the recovery time and prevent complications.
The aim of the present pilot study was to evaluate the effects of a single local dose of strontium chloride on the healing of subcondylar mandibular fractures in rats.
This randomized experimental study was carried out on 24 male Wistar albino rats. The rats were randomly divided into 3 groups: experimental group 1, receiving 3% strontium chloride; experimental group 2, receiving 5% strontium chloride; and the control group. A full thickness surgical osteotomy was created in the subcondylar area. A single dose of strontium solution (0.3 cc/site) was administered locally by injection on the bone surfaces of the fracture line created. Nothing was administered to the control group. The mandibles were dissected on postoperative day 21. The fractured hemimandibles were submitted to histopathological examination.
The median bone fracture healing score was 9 (range: 7-9) in experimental group 1; 8 (range: 7-10) in experimental group 2; and 7.50 (range: 7-8) in the control group. When the groups were compared in terms of bone healing scores, there was a statistically significant difference between experimental group 1 and the control group (p < 0.05).
This study is the first to show that local strontium may have positive effects on the healing of subcondylar mandibular fractures. In the authors' opinion, 3% strontium was beneficial for accelerating facial skeleton consolidation and bone regeneration in rat subcondylar mandibular fractures. This treatment procedure may be combined with closed fracture treatment or a conservative approach.
下颌骨骨折是最常见的面部骨折。可通过保守技术或手术治疗。作者推测，局部单次应用氯化锶可加速髁突下颌骨骨折的愈合，缩短恢复时间并预防并发症。
本初步研究的目的是评估局部单次应用氯化锶对大鼠髁突下颌骨骨折愈合的影响。
本随机实验研究对24只雄性Wistar白化大鼠进行。大鼠被随机分为3组：实验组1，接受3%氯化锶；实验组2，接受5%氯化锶；以及对照组。在髁突区域进行全层手术截骨。通过在骨折线的骨表面注射局部给予单次剂量的锶溶液（0.3 cc/部位）。对照组不给予任何处理。术后第21天解剖下颌骨。将骨折的半侧下颌骨进行组织病理学检查。
实验组1的中位骨折愈合评分是9分（范围：7 - 9分）；实验组2为8分（范围：7 - 10分）；对照组为7.50分（范围：7 - 8分）。当比较各组的骨愈合评分时，实验组1与对照组之间存在统计学显著差异（p < 0.05）。
本研究首次表明局部应用锶可能对髁突下颌骨骨折的愈合有积极作用。作者认为，3%的锶有利于加速大鼠髁突下颌骨骨折的面部骨骼巩固和骨再生。这种治疗方法可与闭合性骨折治疗或保守方法相结合。
