了解血液系统恶性肿瘤中的骨髓微环境：聚焦趋化因子、整合素和细胞外囊泡信号传导。
Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling.
作者信息
Sison Edward Allan Racela, Kurre Peter, Kim Yong-Mi
机构信息
a Department of Pediatrics, Texas Children's Cancer and Hematology Centers , Baylor College of Medicine , Houston , Texas , USA.
b Department of Pediatrics, Doernbecher Children's Hospital , Oregon Health and Science University , Portland , Oregon, USA.
出版信息
Pediatr Hematol Oncol. 2017 Sep-Oct;34(6-7):365-378. doi: 10.1080/08880018.2017.1395938. Epub 2017 Dec 6.
Abstract
Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell-cell crosstalk the bone marrow microenvironment in acute leukemia was presented at the 2016 annual Therapeutic Advances in Childhood Leukemia (TACL) investigator meeting. This review summarizes the mini-symposium proceedings and focuses on chemokine signaling via the cell surface receptor CXCR4, adhesion molecule signaling via integrin α4, and crosstalk between leukemia cells and the bone marrow microenvironment that is mediated through extracellular vesicles.
摘要
白血病细胞与骨髓微环境中的非造血细胞之间的信号传导有助于白血病细胞的生长和存活。这种复杂的化疗耐药外在机制依赖于多种途径和因子，其中一些尚未确定。关于急性白血病骨髓微环境中细胞间相互作用的研究在2016年儿童白血病治疗进展（TACL）年度研究者会议上进行了展示。本综述总结了小型研讨会的会议记录，并重点关注通过细胞表面受体CXCR4的趋化因子信号传导、通过整合素α4的黏附分子信号传导，以及通过细胞外囊泡介导的白血病细胞与骨髓微环境之间的相互作用。
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