Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
PLoS One. 2017 Dec 6;12(12):e0187982. doi: 10.1371/journal.pone.0187982. eCollection 2017.
There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications.
133,401 participants from the UK Biobank cohort were studied. BMI, waist cm and hypertension were compared between those on drugs prescribed for chronic pain and CM drugs to those on CM drugs only. Multiple confounders were controlled for.
Those taking opiates and CM drugs had the worst CM health profile with a 95%, 82% and 63% increased odds of reporting obesity, 'very high risk' waist circumference and hypertension, respectively (OR [95% CI] 1.95 [1.75-2.17], 1.82 [1.63-2.03], 1.63 [1.45-1.84]), compared to those on CM drugs alone. Those taking neuropathic pain medications and CM drugs also demonstrate worse CM profile than those taking CM drugs only.
The impact of medications for chronic pain and sleep upon CM health and obesity is of concern for these classes of drugs which have been recently labelled as dependency forming medications. The results from this cross sectional study warrants further investigation and adds further support to calls for these medications to be prescribed for shorter periods.
治疗慢性非癌性疼痛的药物处方数量显著增加。本研究旨在评估英国人群中使用这些慢性疼痛药物的患者的心脏代谢健康状况。
对英国生物库队列中的 133401 名参与者进行研究。比较了服用慢性疼痛药物和心脏代谢药物与仅服用心脏代谢药物的患者的 BMI、腰围和高血压情况。控制了多种混杂因素。
服用阿片类药物和心脏代谢药物的患者心脏代谢健康状况最差，与仅服用心脏代谢药物的患者相比，报告肥胖、“极高风险”腰围和高血压的几率分别增加了 95%、82%和 63%（OR[95%CI]1.95[1.75-2.17]，1.82[1.63-2.03]，1.63[1.45-1.84]）。与仅服用心脏代谢药物的患者相比，服用神经病理性疼痛药物和心脏代谢药物的患者的心脏代谢状况也更差。
慢性疼痛和睡眠药物对心脏代谢健康和肥胖的影响令人担忧，这些药物最近被标记为易成瘾药物。本横断面研究的结果需要进一步研究，并进一步支持呼吁将这些药物的处方时间缩短。
