Institute of Cardiovascular and Medical Sciences, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Institute of Health & Wellbeing, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Rheumatology (Oxford). 2019 Dec 1;58(12):2137-2142. doi: 10.1093/rheumatology/kez192.
To determine the independent association of central adiposity, assessed by waist circumference, with odds of psoriasis, PsA and RA prevalence after controlling for general adiposity (BMI).
A cross-sectional study of UK Biobank participants aged 40-70 years was performed. Logistic regression was used to calculate the odds of psoriasis, PsA and RA occurrence compared with controls without these conditions by waist circumference, adjusting for covariates: age, sex, smoking status, socioeconomic deprivation and self-reported physical activity (Model 1), followed additionally by BMI (Model 2).
A total of 502 417 participants were included; 5074 with psoriasis (1.02%), 905 with PsA (0.18%), 5532 with RA (1.11%) and 490 906 controls without these conditions. Adjusted odds ratios (ORs) (Model 1) for psoriasis, PsA and RA, per s.d. (13.5 cm) higher waist circumference were 1.20 (95% CI 1.16, 1.23), 1.30 (95% CI 1.21, 1.39) and 1.21 (95% CI 1.17, 1.24), respectively (all P < 0.001). These ORs remained significant after further adjustment for BMI (Model 2) in psoriasis [OR 1.19 (95% CI 1.12, 1.27), P < 0.001] and RA [OR 1.19 (95% CI 1.12, 1.26), P < 0.001], but not in PsA [OR 1.11 (95% CI 0.95, 1.29), P = 0.127].
Central adiposity as measured by waist circumference is associated with greater odds of psoriasis and RA prevalence after adjustment for confounders and for BMI. Our findings add support for central adiposity as a long-term clinically relevant component of these conditions.
在控制一般肥胖（BMI）的情况下，通过腰围评估中心性肥胖与银屑病、PsA 和 RA 患病率的独立相关性。
对英国生物库中年龄在 40-70 岁的参与者进行横断面研究。使用逻辑回归计算与没有这些疾病的对照组相比，银屑病、PsA 和 RA 发生的几率，通过腰围进行调整，并调整协变量：年龄、性别、吸烟状况、社会经济剥夺和自我报告的身体活动（模型 1），然后再加上 BMI（模型 2）。
共纳入 502417 名参与者；其中 5074 名患有银屑病（1.02%），905 名患有 PsA（0.18%），5532 名患有 RA（1.11%），490906 名没有这些疾病的对照组。腰围每增加 1 个标准差（13.5 厘米），银屑病、PsA 和 RA 的调整后比值比（OR）（模型 1）分别为 1.20（95%可信区间 1.16，1.23）、1.30（95%可信区间 1.21，1.39）和 1.21（95%可信区间 1.17，1.24）（均 P < 0.001）。在银屑病（OR 1.19（95%可信区间 1.12，1.27），P < 0.001）和 RA（OR 1.19（95%可信区间 1.12，1.26），P < 0.001）中，这些 OR 在进一步调整 BMI（模型 2）后仍然显著，但在 PsA 中则不然（OR 1.11（95%可信区间 0.95，1.29），P = 0.127）。
通过腰围测量的中心性肥胖与调整混杂因素和 BMI 后银屑病和 RA 患病率的几率增加相关。我们的发现为中心性肥胖作为这些疾病的长期临床相关组成部分提供了更多支持。
