Department of Dermatology, Chaim Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Ramat Gan, Israel.
Dermatology. 2017;233(4):289-294. doi: 10.1159/000481881. Epub 2017 Dec 7.
Alopecia areata is an immune-mediated disease presenting with sudden onset of nonscarring hair loss. Onset is more common earlier in life, and little is known regarding late-onset alopecia areata.
To describe the epidemiology, clinical patterns, disease course, and outcome of late-onset alopecia areata in Israeli patients referred to a tertiary medical center.
This retrospective cohort study considered patients whose disease onset occurred at age ≥50 years. Patients were recruited from among all alopecia areata patients visiting a tertiary center between January 2009 and April 2015.
Of the 29 people included, 25 (86.2%) were female (female-to-male ratio, 6.2:1). There was a family history of alopecia areata in 17.2%, thyroid disease in 31%, atopic background in 6.9%, and 17/29 (58.6%) reported a significant stressful event. The most common disease pattern was patchy, and disease was mild in the majority of participants. Complete hair regrowth was observed in 82.8% of participants, and 37.9% relapsed.
Late-onset alopecia areata is characterized by marked female predominance, less extensive disease, and a high incidence of complete hair regrowth.
斑秃是一种免疫介导的疾病，表现为突然发生非瘢痕性脱发。发病多见于生命早期，而对于晚发性斑秃知之甚少。
描述以色列患者三级医疗中心就诊的晚发性斑秃的流行病学、临床模式、疾病过程和结局。
本回顾性队列研究纳入发病年龄≥50 岁的患者。患者于 2009 年 1 月至 2015 年 4 月期间从三级中心的所有斑秃患者中招募。
共纳入 29 例患者，25 例（86.2%）为女性（女：男比为 6.2：1）。17.2%有斑秃家族史，31%有甲状腺疾病，6.9%有特应性背景，17/29（58.6%）报告有重大应激事件。最常见的疾病模式是斑片状，大多数患者病情较轻。82.8%的患者观察到完全毛发再生，37.9%的患者复发。
晚发性斑秃以明显的女性优势、较少的广泛疾病和高比例的完全毛发再生为特征。
