Li Jinning, Zhang Caiyuan, Cui Yanfen, Liu Huanhuan, Chen Weibo, Wang Guilong, Wang Dengbin
Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Philips Healthcare, Shanghai 200233, China.
Oncotarget. 2017 Oct 11;8(55):94959-94968. doi: 10.18632/oncotarget.21824. eCollection 2017 Nov 7.
To investigate the influence of respiratory-cardiac double triggering (RCT) on intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for the liver, twelve healthy volunteers underwent liver DWI twice respectively with respiratory triggering (RT) and RCT schemes. Signal-to-noise ratios (SNRs) of the images, values, repeatability (evaluating with within-subject coefficient of variation), and variability of quantitative parameters, including apparent diffusion coefficient (ADC), pure diffusion coefficient (), perfusion fraction (), and perfusion-related diffusion coefficient (*), were evaluated for each DWI sequence. Results showed that the use of RCT scheme significantly enhanced SNRs ( < 0.001), improved the measurement precision ( ≤ 0.023) and repeatability ( ≤ 0.009) of ADC, , and values, decreased the variability of ADC and D values ( ≤ 0.015). Furthermore, this improvement was not completely confined to the left liver lobe, but also observed for the right liver lobe. Moreover, the precision of * values in the right lobe ( < 0.001) and its repeatability in the left lobe ( 0.002) were also significantly improved. Thus, our findings suggest that RCT is a more effective physiological scheme for improving SNRs, the precision, repeatability, and variability of quantitative parameters than RT for IVIM-DWI in the liver.
为研究呼吸-心脏双触发（RCT）对肝脏体素内不相干运动（IVIM）扩散加权成像（DWI）的影响，12名健康志愿者分别采用呼吸触发（RT）和RCT方案进行了两次肝脏DWI检查。对每个DWI序列评估图像的信噪比（SNR）、定量参数的值、重复性（用受试者内变异系数评估）以及定量参数的变异性，包括表观扩散系数（ADC）、纯扩散系数（）、灌注分数（）和灌注相关扩散系数（）。结果显示，采用RCT方案可显著提高SNR（<0.001），提高ADC、和值的测量精度（≤0.023）和重复性（≤0.009），降低ADC和D值的变异性（≤0.015）。此外，这种改善并不完全局限于左肝叶，右肝叶也有观察到。而且，右叶值的精度（<0.001）及其在左叶的重复性（0.002）也显著提高。因此，我们的研究结果表明，对于肝脏IVIM-DWI，与RT相比，RCT是一种更有效的生理方案，可提高SNR、定量参数的精度、重复性和变异性。
