Olchik Maira Rozenfeld, Ayres Annelise, Ghisi Marcieli, Schuh Artur Francisco Schumacher, Rieder Carlos Roberto Mello
PhD. Department of Surgery and Orthopedics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, RS, Brazil.
MD. Postgraduate Program in Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre, RS, Brazil.
Dement Neuropsychol. 2016 Oct-Dec;10(4):303-309. doi: 10.1590/s1980-5764-2016dn1004008.
Evidence points to the occurrence of cognitive impairment in all stages of PD, constituting a frequent and debilitating symptom, due to high impact on quality of life and mortality of patients.
To correlate cognitive performance with quality of life in PD.
The sample was drawn from a Movement Disorders Clinic of a reference hospital in Porto Alegre. Inclusion criteria were: PD diagnosis, according to the United Kingdom Parkinson's Disease Society Brain Bank criteria for idiopathic PD (Hughes et al. 1992) and patient consent to participate. Patients with other neurological pathologies and those submitted to deep brain stimulation were excluded. The evaluation consisted of a cognitive testing battery (composed of eight tests for assessing cognitive performance), and a questionnaire on quality of life (PDQ-39) and depression (BDI).
The sample comprised 85 individuals with PD, with a mean age of 62.9 years (±10.7), mean disease duration of 10.4 years (±5.7), and mean educational level of four years (±4.3). There was a significant relationship between total score on the PDQ and all cognitive tests, showing that poor cognitive performance was correlated with poor quality of life. Moreover, a significant correlation was observed between cognitive tests and depression, H&Y, education level, and age.
It may be concluded that the individuals with PD in this sample showed a correlation between poorer quality of life and worse cognitive performance. Poor performance was also correlated with more advanced stage, older age, low level of education and depression.
有证据表明帕金森病（PD）各阶段均会出现认知障碍，这是一种常见且使人衰弱的症状，因为它对患者的生活质量和死亡率有很大影响。
探讨PD患者认知功能与生活质量的相关性。
样本取自阿雷格里港一家参考医院的运动障碍诊所。纳入标准为：根据英国帕金森病协会脑库的特发性PD标准（Hughes等人，1992年）确诊为PD，且患者同意参与。排除患有其他神经病理学疾病的患者以及接受深部脑刺激的患者。评估包括一组认知测试（由八项评估认知功能的测试组成）、一份生活质量问卷（PDQ - 39）和一份抑郁问卷（BDI）。
样本包括85例PD患者，平均年龄62.9岁（±10.7），平均病程10.4年（±5.7），平均教育水平为4年（±4.3）。PDQ总分与所有认知测试之间存在显著相关性，表明认知功能差与生活质量差相关。此外，认知测试与抑郁、H&Y分级、教育水平和年龄之间也存在显著相关性。
可以得出结论，该样本中的PD患者生活质量较差与认知功能较差之间存在相关性。认知功能差还与疾病晚期、年龄较大、教育水平低和抑郁相关。
