Mukadam Nishaat, Kinger Shraddha B, Neargarder Sandy, Salazar Robert D, McDowell Celina Pluim, Wall Juliana, Kaplan Rini I, Cronin-Golomb Alice
Department of Psychological and Brain Sciences, Boston University, 900 Commonwealth Ave., 2nd Floor, Boston, MA 02215, USA.
Department of Psychology, Bridgewater State University, Bridgewater, MA 02324, USA.
Healthcare (Basel). 2025 Jan 2;13(1):70. doi: 10.3390/healthcare13010070.
Social isolation and health-related consequences of the COVID-19 pandemic may have significantly impacted quality of life in people with Parkinson's disease (PwPD). The effect of the COVID-19 pandemic specifically on subjective cognition and social functioning in PwPD is poorly understood. We conducted a longitudinal analysis of changes in subjective cognitive and social functioning in PwPD before (T1, 2017-2019) and during (T2, 2021) the COVID-19 pandemic. At T1, 347 PwPD completed online surveys. At T2, 123 of them (54 males, 69 females) responded to follow-up questionnaires including Quality of Life in Neurological Disorders (Neuro-QoL) subscales, Beck Depression Inventory-II, Parkinson's Anxiety Scale, motor and non-motor experiences of daily living from the MDS-Unified Parkinson's Disease Rating Scale, and the Coronavirus Impact Scale. T1-T2 declines in subjective cognition and social functioning both were correlated with more anxiety, fatigue, and motor symptoms. Additionally, declines in subjective cognition correlated with depression, and with decline in social functioning. Women reported greater COVID-19 impact than men, unrelated to cognition and social functioning; in men, personal experience with COVID-19 was associated with decline in subjective cognition. Our finding that subjective cognition and social functioning are associated with different motor and non-motor symptoms of PD suggests that the impacts of PD on subjective cognition and social functioning are complex, which has important implications for treatment.
新冠疫情导致的社交隔离及与健康相关的后果可能对帕金森病患者（PwPD）的生活质量产生了重大影响。目前人们对新冠疫情对PwPD主观认知和社交功能的具体影响了解甚少。我们对PwPD在新冠疫情之前（T1，2017 - 2019年）和期间（T2，2021年）主观认知和社交功能的变化进行了纵向分析。在T1时，347名PwPD完成了在线调查。在T2时，其中123人（54名男性，69名女性）回复了后续问卷，包括神经疾病生活质量（Neuro - QoL）子量表、贝克抑郁量表第二版、帕金森焦虑量表、来自MDS统一帕金森病评定量表的运动和非运动日常生活体验以及新冠病毒影响量表。主观认知和社交功能从T1到T2的下降均与更多的焦虑、疲劳和运动症状相关。此外，主观认知的下降与抑郁以及社交功能的下降相关。女性报告的新冠疫情影响比男性更大，这与认知和社交功能无关；在男性中，感染新冠病毒的个人经历与主观认知的下降有关。我们的研究发现，主观认知和社交功能与帕金森病不同的运动和非运动症状相关，这表明帕金森病对主观认知和社交功能的影响是复杂的，这对治疗具有重要意义。
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