抗TNF-α药物对阿尔茨海默病进展的作用：一例报告。
Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report.
作者信息
Camargo Carlos Henrique Ferreira, Justus Filipe Fernandes, Retzlaff Giuliano, Blood Marcelo Rezende Young, Schafranski Marcelo Derbli
机构信息
Neurology Service, Medicine Department, Hospital Universitário - State University of Ponta Grossa, Ponta Grossa, Brazil.
Rheumatology Service, Medicine Department, Hospital Universitário - State University of Ponta Grossa, Ponta Grossa, Brazil.
出版信息
Dement Neuropsychol. 2015 Apr-Jun;9(2):196-200. doi: 10.1590/1980-57642015DN92000015.
The aim of this study was to describe a clinical case of a patient with Alzheimer's disease (AD) in use of an anti-TNF-α agent for rheumatoid arthritis (RA). The patient reported is an 81-year-old Caucasian man and retired teacher, diagnosed with RA in 2008 and AD in 2011. Treatment with donepezil was started in 2011 and the use of etanercept introduced in 2012. He was previously treated with adalimumab in 2010 for 18 months. In 2013, the subject was engaged in a clinical trial to assess a complementary non-pharmacological approach for AD, presenting significant cognitive improvement during the follow-up period. We propose the hypothesis of a synergistic effect of anti-TNF-α medication used for the treatment of RA as the cause of the improvement in cognitive response observed. These findings could suggest a possible use of this drug class in the therapeutic management of AD.
本研究的目的是描述一名患有阿尔茨海默病（AD）的患者使用抗TNF-α药物治疗类风湿关节炎（RA）的临床病例。报告的患者是一名81岁的白人男性，退休教师，2008年被诊断为RA，2011年被诊断为AD。2011年开始使用多奈哌齐治疗，2012年开始使用依那西普。他曾在2010年接受阿达木单抗治疗18个月。2013年，该患者参与了一项评估AD补充非药物治疗方法的临床试验，在随访期间认知功能有显著改善。我们提出假设，用于治疗RA的抗TNF-α药物的协同作用是观察到的认知反应改善的原因。这些发现可能提示这类药物在AD治疗管理中的潜在应用。
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