Mostafaei Shayan, Norooznezhad Fatemeh, Mohammadi Saeed, Norooznezhad Amir Hossein
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Rheumatology Research Center, Tehran University of Medical Sciences, Iran.
Wound Repair Regen. 2017 Nov;25(6):1002-1007. doi: 10.1111/wrr.12597. Epub 2018 Feb 7.
Pilonidal disease (PD) is a chronic situation which may cause pain, discomfort, inflammation, discharges, and inability to do daily routines. Among two main methods of surgery, open healing is preferred by surgeons since it associates with lower risk of recurrence; however, it could complicate the wound condition by delaying the healing process. For this meta-analysis, a search in Medline, Embase, and Scopus was performed in June 2017 with no restrictions placed on the publication date or languages. Then, time to healing was considered as the effect size and all the data from trials were extracted. The heterogeneity and the variation in pooled estimation were assessed using Cochran's Q test and I-squared, respectively. Meta-regression was used to examine the relationship between the effect size and year, studies' sample sizes, proportion of male gender and age with the cause of heterogeneity. From 11 selected articles finally 4 met our inclusion and exclusion criteria with the total number of 484 patients. Using a fixed-effect model, pool effect was detected 0.642 (95% CI: 0.485-0.798). A homogeneity of pooled effect size estimate for the studies was also found (Cochran Q test, p-value = 0.844, I-square = 0.0%). Moreover, results of meta-regression showed no statistically significant association between the effect size and patients' mean age, year of publication, total sample size, and sex proportion (0.51 < p-values < 0.98). Platelet-rich plasma therapy for PD wounds appeared more effective than classic wound dressing.
藏毛窦疾病（PD）是一种慢性病症，可能会导致疼痛、不适、炎症、分泌物增多以及无法进行日常活动。在两种主要的手术方法中，外科医生更倾向于开放愈合，因为其复发风险较低；然而，它可能会因延迟愈合过程而使伤口状况复杂化。对于这项荟萃分析，2017年6月在Medline、Embase和Scopus数据库中进行了检索，对发表日期和语言均无限制。然后，将愈合时间视为效应量，并提取试验中的所有数据。分别使用Cochran's Q检验和I²统计量评估合并估计中的异质性和变异性。采用Meta回归分析效应量与年份、研究样本量、男性比例和年龄之间的关系以及异质性的原因。最终从11篇选定的文章中，有4篇符合我们的纳入和排除标准，患者总数为484例。采用固定效应模型，检测到合并效应量为0.642（95%CI：0.485 - 0.798）。还发现各研究合并效应量估计具有同质性（Cochran Q检验，p值 = 0.844，I² = 0.0%）。此外，Meta回归结果显示效应量与患者平均年龄、发表年份、总样本量和性别比例之间无统计学显著关联（0.51 < p值 < 0.98）。富含血小板血浆疗法对PD伤口似乎比传统伤口敷料更有效。
