Johnston C S
Department of Family Resources and Human Development, Arizona State University, Tempe 85287.
J Nutr. 1989 Mar;119(3):425-7. doi: 10.1093/jn/119.3.425.
A series of experiments were conducted to examine the effect of single oral doses of ascorbic acid on body temperature in healthy guinea pigs. Fifteen male guinea pigs (approximately 200 g) were fed a nonpurified diet designed for rabbits (a scorbutogenic diet) ad libitum and received orally 2 mg L-ascorbic acid/100 g body wt daily. After acclimation, rectal temperatures were recorded hourly following five separate ascorbate dosage treatments: 0 (control dosage), 2, 10 or 50 mg ascorbic acid/100 g body wt, or 50 mg ascorbic acid and 0.07 mg indomethacin/100 g body wt. Mean body temperature was significantly elevated (P less than 0.05) after 1 h in animals receiving either the 10 or 50 mg dosage (+ 0.27 +/- 0.05 and + 0.41 +/- 0.07 degree C, respectively) compared to that in animals receiving the 2 mg dosage (-0.07 +/- 0.05 degree C), the recommended daily intake for guinea pigs. Changes in body temperature of animals receiving the 50 mg dosage plus indomethacin did not differ significantly from those reported with the 2 mg dosage. Thus, a single oral dose of ascorbic acid at levels 5-25 times the recommended intake, can elevate body temperature significantly in healthy guinea pigs, a phenomenon which is inhibited by indomethacin administration.
进行了一系列实验，以研究单次口服抗坏血酸对健康豚鼠体温的影响。15只雄性豚鼠（约200克）随意喂食专为兔子设计的非纯化日粮（致坏血病日粮），并每日口服2毫克L-抗坏血酸/100克体重。适应环境后，在五种不同的抗坏血酸剂量处理后每小时记录直肠温度：0（对照剂量）、2、10或50毫克抗坏血酸/100克体重，或50毫克抗坏血酸和0.07毫克吲哚美辛/100克体重。与接受2毫克剂量（-0.07±0.05℃）的动物相比，接受10毫克或50毫克剂量（分别为+0.27±0.05和+0.41±0.07℃）的动物在1小时后平均体温显著升高（P<0.05），2毫克剂量是豚鼠的推荐每日摄入量。接受50毫克剂量加吲哚美辛的动物体温变化与接受2毫克剂量的动物无显著差异。因此，单次口服剂量为推荐摄入量5-25倍的抗坏血酸可使健康豚鼠体温显著升高，吲哚美辛给药可抑制这一现象。
