抗坏血酸对坏血病豚鼠组胺代谢的影响。
Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs.
作者信息
Chatterjee I B, Gupta S D, Majumder A K, Nandi B K, Subramanian N
出版信息
J Physiol. 1975 Oct;251(2):271-9. doi: 10.1113/jphysiol.1975.sp011091.
Abstract
- In guinea-pigs fed an ascorbic-acid-free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10-12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea-pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic-acid-depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea-pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.
摘要
- 在喂食无抗坏血酸饮食的豚鼠中，随着抗坏血酸水平降低，血液和尿液中的组胺水平在约10 - 12天内稳步上升至最大值。坏血病豚鼠血液和尿液中的组胺水平持续升高，肺、胃黏膜和脾脏中的组胺水平也增加。通过给予单剂量5毫克/100克体重的抗坏血酸，可使抗坏血酸缺乏状态下尿液、血液和其他组织中增加的组胺含量恢复到正常水平。3. 升高的组胺水平下降并非由于抗坏血酸对组胺形成能力、组胺酶活性或组胺释放的间接作用。
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