Department of Health Science, California State University, Long Beach, Long Beach, CA, USA; Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA; Center for Patient Care and Outcomes Research (PCOR), Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Department of Health Science, California State University, Long Beach, Long Beach, CA, USA.
J Diabetes Complications. 2018 Feb;32(2):139-143. doi: 10.1016/j.jdiacomp.2017.11.005. Epub 2017 Nov 11.
ACEs are known to increase risk for diabetes in adulthood. However, little is known about the differential impact of individual ACE categories on diabetes risk, and whether this relationship is gender specific.
Data from the 2011 BRFSS was used in this study. Participants included 48,526 adults who completed the ACE module across 5 states. Using logistic regression, we examined the odds of diabetes in adulthood related to eight individual categories of ACEs: sexual abuse, physical abuse, verbal abuse, mental illness, substance abuse, incarceration, separation/divorce, and violence. A gender interaction term was included to test if this relationship varied between men and women.
In adjusted analyses, sexual abuse (OR 1.57, CI 1.240; 1.995) had the strongest positive association followed by verbal (OR 1.29, CI 1.117; 1.484) and physical abuse (OR 1.26, CI 1.040; 1.516). Having a parent with mental illness was also significantly associated with increased odds of diabetes (OR 1.19, CI 0.996; 1.416). No interaction between ACEs and diabetes status by gender in any of the eight categories was found.
Overall, this study found that four ACE categories were significantly associated with increased odds of diabetes in adulthood with sexual abuse being the strongest predictor.
已知 ACE 会增加成年后患糖尿病的风险。然而，对于个体 ACE 类别对糖尿病风险的差异影响知之甚少，也不清楚这种关系是否具有性别特异性。
本研究使用了来自 2011 年 BRFSS 的数据。参与者包括来自 5 个州的 48526 名完成 ACE 模块的成年人。我们使用逻辑回归检验了与 ACE 的 8 个个体类别相关的成年后患糖尿病的几率：性虐待、身体虐待、言语虐待、精神疾病、药物滥用、监禁、分离/离婚和暴力。纳入性别交互项以检验这种关系在男性和女性之间是否存在差异。
在调整后的分析中，性虐待（OR 1.57，CI 1.240；1.995）与糖尿病之间呈最强的正相关，其次是言语虐待（OR 1.29，CI 1.117；1.484）和身体虐待（OR 1.26，CI 1.040；1.516）。父母患有精神疾病也与糖尿病几率增加显著相关（OR 1.19，CI 0.996；1.416）。在任何 8 个类别中，ACE 和糖尿病状态之间均未发现性别交互作用。
总的来说，这项研究发现，4 个 ACE 类别与成年后患糖尿病的几率增加显著相关，其中性虐待是最强的预测因素。
