Pak Stella, Logemann Shaina, Dee Christine, Fershko Adam
Internal Medicine, Kettering Medical Center.
Wright State University Boonshoft School of Medicine.
Cureus. 2017 Oct 4;9(10):e1743. doi: 10.7759/cureus.1743.
Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome refers to a condition in which features of Behcet's disease (BD) and relapsing polychondritis (RP) occur in the same individual. The existence of MAGIC syndrome suggests a potential common etiology for BD and RP. However, connecting these two diseases and referring to this condition as MAGIC syndrome might have been premature, as there is currently insufficient knowledge on BD and RP. In this critical review, we argue that these two clinical entities could possibly be unique disease processes rather than two ends of the same disease spectrum. Distinguishing the clinical difference between BD and RP is critical for the management of patients diagnosed with MAGIC syndrome, as biological therapeutic approaches for BD and RP differ. Also, inaccurate perception regarding the relationship of these two diseases could mislead researchers in their endeavors to unravel the pathophysiological mechanisms behind these two diseases.
口生殖器溃疡伴软骨炎（MAGIC）综合征是指白塞病（BD）和复发性多软骨炎（RP）的特征出现在同一个体中的一种病症。MAGIC综合征的存在提示BD和RP可能存在共同的病因。然而，将这两种疾病联系起来并将这种情况称为MAGIC综合征可能为时过早，因为目前对白塞病和复发性多软骨炎的了解还不够充分。在这篇批判性综述中，我们认为这两种临床实体可能是独特的疾病过程，而不是同一疾病谱的两端。区分BD和RP的临床差异对于诊断为MAGIC综合征的患者的管理至关重要，因为BD和RP的生物治疗方法不同。此外，对这两种疾病关系的不准确认识可能会误导研究人员努力揭示这两种疾病背后的病理生理机制。
