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A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling.
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Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.
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IL-17 and Th17 Cells.
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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
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