Zhao Q S, Ren Z, Zhang H L, Dai J L, Wang J, Yu F, Huang J
Department of Forensic Medicine, Guizhou Medical University, Guiyang 550025, China.
Guizhou Province Population and Family Planning Institute of Justice, Guiyang 550004, China.
Fa Yi Xue Za Zhi. 2017 Aug;33(4):388-392. doi: 10.3969/j.issn.1004-5619.2017.04.012. Epub 2017 Aug 25.
To investigate the allelic distribution of 19 autosomal STR loci in Guizhou Han population, and to estimate the forensic application value.
The 19 autosomal STR loci in 520 unrelated healthy individuals from Guizhou Han population were studied using Goldenye™ 20A kit. The 310 genetic analyzer was used for capillary electrophoresis, and the GeneMapper®ID v3.1 for genotyping.
The heterozygosis, the discrimination power, the probability of exclusion, the polymorphism information content, the cumulative discrimination power and the cumulative probability of exclusion of the 19 STR loci were 0.603 8-0.916 4, 0.790 0-0.985 6, 0.295 5-0.826 9, 0.553 5-0.908 9, 1-1.230 0×10⁻²² and 0.999 999 99, respectively. Compared with other five Han populations in pairwise allelic frequencies, Guizhou Han only had significant differences with Shandong Han, Liaoning Han and Shanxi Han.
The 19 autosomal STR loci such as have a highly genetic polymorphic in Guizhou Han population, which have application values in the researches of population genetics and forensic genetics.
研究贵州汉族人群19个常染色体STR基因座的等位基因分布，并评估其法医学应用价值。
采用Goldeneye™ 20A试剂盒对520名贵州汉族无关健康个体的19个常染色体STR基因座进行研究。使用310遗传分析仪进行毛细管电泳，采用GeneMapper®ID v3.1进行基因分型。
19个STR基因座的杂合度、个体识别力、非父排除率、多态信息含量、累积个体识别力和累积非父排除率分别为0.603 8 - 0.916 4、0.790 0 - 0.985 6、0.295 5 - 0.826 9、0.553 5 - 0.908 9、1 - 1.230 0×10⁻²²和0.999 999 99。与其他五个汉族人群进行两两等位基因频率比较，贵州汉族仅与山东汉族、辽宁汉族和山西汉族存在显著差异。
贵州汉族人群中如 等19个常染色体STR基因座具有高度遗传多态性，在群体遗传学和法医学遗传学研究中有应用价值。
