School of Chemistry and Chemical Engineering, ‡Sixth People's Hospital South Campus, and §Zhiyuan College, Shanghai Jiao Tong University , Shanghai 200240, P. R. China.
Org Lett. 2017 Apr 7;19(7):1764-1767. doi: 10.1021/acs.orglett.7b00442. Epub 2017 Mar 14.
An efficient and convenient copper-catalyzed method has been developed to achieve direct ortho-C-H/N-H annulation to synthesize phenanthridinones with arynes. This method highlights an emerging strategy to transform inert C-H bonds into versatile functional groups in organic synthesis and provides a new way to synthesize phenanthridinone alkaloids efficiently.
发展了一种高效、便捷的铜催化方法，实现了芳炔与邻位 C-H/N-H 的直接环化反应，合成了菲啶酮类化合物。该方法为在有机合成中转化惰性 C-H 键为多功能基团提供了一种新策略，为高效合成菲啶酮类生物碱提供了新途径。
