Department of Neurology, Washington University School of Medicine, St Louis, MO.
Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO.
Ann Neurol. 2018 Jan;83(1):197-204. doi: 10.1002/ana.25117.
Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase Alzheimer disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with C -leucine to measure amyloid β kinetics. We found that sleep deprivation increased overnight amyloid β38, amyloid β40, and amyloid β42 levels by 25 to 30% via increased overnight amyloid β production relative to sleeping controls. These findings suggest that disrupted sleep increases Alzheimer disease risk via increased amyloid β production. Ann Neurol 2018;83:197-204.
睡眠障碍与未来患阿尔茨海默病的风险有关。睡眠中断会增加可溶性淀粉样蛋白 β，提示睡眠障碍增加阿尔茨海默病风险的机制。我们使用留置腰椎导管在参与者睡眠剥夺、服用羟丁酸钠或允许正常睡眠时，连续采集脑脊液样本，在人类中测试了这种反应。所有参与者均接受 C-亮氨酸输注以测量淀粉样蛋白 β 动力学。我们发现，与睡眠对照组相比，睡眠剥夺通过增加夜间淀粉样蛋白 β 的产生，使夜间淀粉样蛋白 β38、β40 和 β42 水平增加了 25%至 30%。这些发现表明，睡眠中断通过增加淀粉样蛋白 β 的产生增加了阿尔茨海默病的风险。神经病学杂志 2018;83:197-204.
