低血清铁蛋白和葡萄糖-6-磷酸脱氢酶缺乏作为尼日利亚埃努古总理关怀医院就诊孕妇贫血的潜在预测指标。
Low serum ferritin and G6PD deficiency as potential predictors of anaemia in pregnant women visiting Prime Care Hospital Enugu Nigeria.
作者信息
Engwa Godwill Azeh, Unaegbu Marcellus, Unachukwu Marian N, Njoku Mary-Gloria C, Agbafor Kingsley N, Mbacham Wilfred Fon, Okoh Anthony
机构信息
Biochemistry, Department of Chemical Sciences, Faculty of Natural and Applied Sciences, Godfrey Okoye University, P.M.B 01014, Thinkers Corner, Enugu, Nigeria.
Department of Microbiology, Faculty of Natural and Applied Sciences, Godfrey Okoye University, P.M.B 01014, Thinkers Corner, Enugu, Nigeria.
出版信息
BMC Res Notes. 2017 Dec 8;10(1):721. doi: 10.1186/s13104-017-3051-5.
OBJECTIVES
Though iron deficiency is known to be a major risk factor of anaemia, the association of G6PD deficiency and malaria with anaemia still remains unclear. Hence, a cross-sectional study involving 95 pregnant women visiting Prime Care Hospital in Trans-Ekulu region of Enugu Nigeria was conducted to determine possible predictors of anaemia in pregnancy.
RESULTS
The prevalence of anaemia, malaria and G6PD deficiency were 53.7, 12.6 and 60% respectively. Low serum ferritin (OR 5.500, CI 2.25-13.42, p < 0.05) and G6PD deficiency (OR 0.087, CI 0.03-0.23, p < 0.05) were associated with anaemia in pregnancy. On the other hand, malaria did not significantly associate (OR 1.184, CI 0.35-3.97, p = 0.964) with anaemia in pregnant women. These findings showed high prevalence of anaemia among pregnant women with low serum ferritin level and G6PD deficiency as high risk factors of anaemia.
目的
尽管缺铁是已知的贫血主要危险因素，但葡萄糖-6-磷酸脱氢酶（G6PD）缺乏和疟疾与贫血之间的关联仍不明确。因此，在尼日利亚埃努古跨埃库卢地区的总理关怀医院对95名孕妇进行了一项横断面研究，以确定妊娠贫血的可能预测因素。
结果
贫血、疟疾和G6PD缺乏的患病率分别为53.7%、12.6%和60%。低血清铁蛋白（比值比5.500，可信区间2.25 - 13.42，p < 0.05）和G6PD缺乏（比值比0.087，可信区间0.03 - 0.23，p < 0.05）与妊娠贫血相关。另一方面，疟疾与孕妇贫血无显著关联（比值比1.184，可信区间0.35 - 3.97，p = 0.964）。这些发现表明，血清铁蛋白水平低和G6PD缺乏的孕妇中贫血患病率高，它们是贫血的高危因素。
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