INSERM, UMRS1131-Paris Diderot University, Saint Louis Hospital, Paris, France.
Cell Biology Department, APHP, Saint Louis Hospital, Paris, France.
Cell Mol Life Sci. 2018 Apr;75(8):1377-1391. doi: 10.1007/s00018-017-2725-4. Epub 2017 Dec 8.
The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment.
骨髓微环境 (BMM) 调节造血干细胞 (HSCs) 在稳态和病理条件下的命运。在髓系恶性肿瘤中,人们对 BMM 及其在疾病进展中细胞和分子作用者的作用的新认识开始出现。在这篇综述中,我们将重点描述 HSC 龛的主要参与者以及改变的龛功能在髓系恶性肿瘤中的作用,更具体地说,重点关注间充质基质细胞区室。