Paterniti Irene, Esposito Emanuela, Cuzzocrea Salvatore
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Messina, Italy.
Methods Mol Biol. 2018;1727:379-384. doi: 10.1007/978-1-4939-7571-6_29.
Animal spinal cord injury (SCI) models have proven highly useful for investigating the mechanisms involved in the injury process and evaluating the effectiveness of experimental therapeutic interventions. Over the last years, substantial improvements have been made in producing consistent and reproducible animal SCI models. Different SCI models have been developed to address the mechanism of injury, being divided into contusion, compression, distraction, dislocation, transection, or chemical models. The method described here is a mouse compression model of SCI that, in many respects, faithfully reproduces SCI in man.
动物脊髓损伤（SCI）模型已被证明在研究损伤过程中涉及的机制以及评估实验性治疗干预措施的有效性方面非常有用。在过去几年中，在建立一致且可重复的动物SCI模型方面取得了重大进展。已经开发出不同的SCI模型来研究损伤机制，这些模型分为挫伤、压迫、牵张、脱位、横断或化学模型。这里描述的方法是一种小鼠SCI压迫模型，在许多方面都能如实地重现人类的SCI。
