评估多发性硬化症中增大的血管周围空间与疾病恶化之间的关联。
Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis.
机构信息
Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
出版信息
J Neuroimaging. 2018 May;28(3):273-277. doi: 10.1111/jon.12490. Epub 2017 Dec 11.
BACKGROUND AND PURPOSE
Enlarged perivascular spaces (EPVSs) have been associated with relapses and brain atrophy in multiple sclerosis (MS). We investigated the association of EPVS with clinical and MRI features of disease worsening in a well-characterized cohort of relapsing-remitting MS patients prospectively followed for up to 10 years.
METHODS
Baseline EPVSs were scored on 1.5T MRI in 30 converters to moderate-severe disability, and 30 nonconverters matched for baseline characteristics.
RESULTS
EPVS scores were not significantly different between converters and nonconverters, nor associated with accrual of lesions or brain atrophy.
CONCLUSIONS
Our preliminary findings from a relatively small study sample argue against a potential use of EPVS as early indicator of risk for disease worsening in relapsing-remitting MS patients in a clinical setting. Although the small sample size and clinical 1.5T MRI may have limited our ability to detect a significant effect, we provided estimates of the association of EPVS with clinical and MRI indicators of disease worsening in a well-characterized cohort of MS patients.
背景与目的
扩大的血管周围间隙（EPVS）与多发性硬化症（MS）的复发和脑萎缩有关。我们在一个经过充分特征描述的复发缓解型 MS 患者队列中进行了前瞻性研究，这些患者在 10 年内接受了随访，旨在探讨 EPVS 与疾病恶化的临床和 MRI 特征之间的关联。
方法
在 30 名进展为中重度残疾的转化者和 30 名基线特征匹配的非转化者中，在 1.5T MRI 上对基线 EPVS 进行评分。
结果
转化者和非转化者之间的 EPVS 评分无显著差异，也与病灶的累积或脑萎缩无关。
结论
我们从相对较小的研究样本中获得的初步发现表明，EPVS 不太可能作为复发缓解型 MS 患者临床疾病恶化风险的早期指标。尽管小样本量和临床 1.5T MRI 可能限制了我们检测显著效果的能力，但我们提供了 EPVS 与 MS 患者队列中疾病恶化的临床和 MRI 指标的关联的估计。
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