Hornstra G, Haddeman E, Don J A
Department of Nutrition and Safety, Unilever Research, Vlaardingen, The Netherlands.
Thromb Res. 1989 Jan 1;53(1):45-53. doi: 10.1016/0049-3848(89)90114-x.
Rats, deficient in essential fatty acids (EFA), were given diets containing 5 energy% sunflowerseed oil (SO, rich in linoleic acid), cod-liver oil (CLO, rich in timnodonic acid and cervonic acid), or hydrogenated coconut oil (HCO), containing no EFAs at all. SO and CLO feeding resulted in normalization of the reduced arterial thrombus formation in EFA-deficient animals. SO feeding was associated with the normalization of the arachidonic acid content of platelet phospholipids. CLO feeding did not have this effect but greatly increased the availability of timnodonic acid (EPA) and cervonic acid (DHA). Further research is required to investigate whether these changes in fatty acid composition can be hold responsible for the normalizing effect of dietary CLO on the disturbed arterial thrombosis tendency in EFA deficient rats, possibly via the formation of eicosanoids.
给缺乏必需脂肪酸（EFA）的大鼠喂食含有5%能量的向日葵籽油（SO，富含亚油酸）、鱼肝油（CLO，富含二十碳五烯酸和二十二碳六烯酸）或完全不含必需脂肪酸的氢化椰子油（HCO）的日粮。喂食SO和CLO可使EFA缺乏动物中降低的动脉血栓形成恢复正常。喂食SO与血小板磷脂中花生四烯酸含量的正常化有关。喂食CLO没有这种效果，但大大增加了二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的可利用性。需要进一步研究来调查这些脂肪酸组成的变化是否可能通过类花生酸的形成，对日粮CLO对EFA缺乏大鼠紊乱的动脉血栓形成倾向的正常化作用负责。
