Department of Psychiatry and Psychotherapy Tübingen, University of Tübingen, Germany.
Graduate School of Neural and Behavioural Sciences Tübingen, Germany.
J Stud Alcohol Drugs. 2018 Jan;79(1):137-147.
Cue reactivity is an automatic reaction to alcohol-related cues, contributing to the maintenance of drinking behavior and relapse in alcohol dependency. The identification of valid cue-reactivity features is a prerequisite for its clinical application. We were interested in the effects of visual features of alcohol cues (e.g., color) on cue reactivity. Assuming its development at a pre-pathological stage, we analyzed cue reactivity in heavy social drinkers, with light social drinkers as controls. We investigated whether cue reactivity was independent of visual features at an attentional (P100) and a motivational level (late positive potential, LPP).
Event-related potentials (ERPs; P100, LPP) were analyzed during a visual beverage classification task in heavy social drinkers and light social drinkers (N = 34 university students). Photographs of beverages were classified as alcoholic or nonalcoholic. Two additional stimulus sets depicted unrecognizable scrambled visual information and recognizable black silhouettes of the original beverages. Analysis of contrast waves inferred content (unrecognized scrambled trials subtracted from original) and color information (recognized shape trials subtracted from original) during visual processing. Linear regression was used to predict Alcohol Use Disorders Identification Test (AUDIT) scores from ERPs.
In heavy social drinkers, alcoholic-content LPP was increased and P100 latency was shorter compared with nonalcoholic cues. Linear regression for alcohol content condition in the overall sample revealed shorter P100 latency and increased LPP amplitude predicting AUDIT scores. None of those effects were significant in the visual-feature control condition.
Alcohol cue reactivity in heavy social drinkers was related to faster early attentional processes and motivational salience. The effect occurred independently of visual features in the pictures.
线索反应是对与酒精相关线索的自动反应，有助于维持饮酒行为和酒精依赖的复发。识别有效的线索反应特征是其临床应用的前提。我们对酒精线索的视觉特征（例如颜色）对线索反应的影响感兴趣。假设其在病理性前阶段发展，我们分析了重度社交饮酒者的线索反应，以轻度社交饮酒者作为对照。我们研究了线索反应是否独立于注意力水平（P100）和动机水平（晚期正电位，LPP）的视觉特征。
在重度社交饮酒者和轻度社交饮酒者（N=34 名大学生）的视觉饮料分类任务中分析事件相关电位（ERPs；P100、LPP）。饮料照片被分类为含酒精或不含酒精。另外两个刺激集描绘了无法识别的混乱视觉信息和原始饮料的可识别黑色轮廓。在视觉处理过程中，分析对比波推断内容（原始减去无法识别的混乱试验）和颜色信息（原始减去可识别的形状试验）。线性回归用于从 ERPs 预测酒精使用障碍识别测试（AUDIT）评分。
与非酒精线索相比，重度社交饮酒者的酒精内容 LPP 增加，P100 潜伏期缩短。对总体样本中酒精含量条件的线性回归显示，P100 潜伏期缩短和 LPP 幅度增加预测 AUDIT 评分。在视觉特征对照条件下，这些效应均不显著。
重度社交饮酒者的酒精线索反应与更快的早期注意力过程和动机显著性有关。该效应独立于图片中的视觉特征。
