Yu C, Wang J, Wang F, Han X, Hu H, Yuan J, Miao X, Yao P, Wei S, Wang Y, Liang Y, Chen W, Zhang X, Guo H, Yang H, Tang Y, Zheng D, Wu T, He M
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, Hubei, China.
Nutr Metab Cardiovasc Dis. 2018 Mar;28(3):278-284. doi: 10.1016/j.numecd.2017.11.009. Epub 2017 Dec 7.
Plasma homocysteine concentrations have been reported to be associated with type 2 diabetes mellitus (T2DM) with controversial findings. The aim of the present study was to investigate the association between plasma homocysteine concentrations and T2DM.
A cross-sectional study including 19,085 eligible participants derived from the Dongfeng-Tongji cohort was conducted. Plasma homocysteine concentrations were measured by Abbott Architect i2000 Automatic analyzer and T2DM was defined according to American Diabetes Association criteria. Logistic regression model was used to explore the association between plasma homocysteine concentrations and T2DM. The prevalence of T2DM was 19.0% in the whole population (mean age 62.9 years), 21.8% in males, and 17.1% in females. In the multivariable logistic regression analyses, compared with those in the lowest quintile, the OR (95% CI) of T2DM was 1.05 (0.92-1.21), 0.99 (0.86-1.14), 0.90 (0.78-1.05), and 0.77 (0.66-0.90) for quintile 2 to quintile 5 of homocysteine concentrations after adjustment for potential confounders (P for trend < 0.0001). Homocysteine concentrations were associated with decreased T2DM prevalence risk (OR = 0.88 per SD increase of homocysteine concentration; 95% CI: 0.84-0.93). A significant interaction between homocysteine concentrations and drinking status on T2DM prevalence risk was observed (P for interaction = 0.03). The inverse association of plasma homocysteine concentrations with T2DM prevalence risk was observed in non-drinkers but not in current drinkers.
Plasma homocysteine concentrations were inversely correlated with T2DM among a middle-aged and elderly Chinese population.
血浆同型半胱氨酸浓度与2型糖尿病（T2DM）之间的关系已有报道，但结果存在争议。本研究旨在探讨血浆同型半胱氨酸浓度与T2DM之间的关联。
进行了一项横断面研究，纳入了来自东风-同济队列的19,085名符合条件的参与者。采用雅培Architect i2000自动分析仪测定血浆同型半胱氨酸浓度，并根据美国糖尿病协会标准定义T2DM。使用逻辑回归模型探讨血浆同型半胱氨酸浓度与T2DM之间的关联。T2DM在整个人群中的患病率为19.0%（平均年龄62.9岁），男性为21.8%，女性为17.1%。在多变量逻辑回归分析中，在调整潜在混杂因素后，与最低五分位数相比，同型半胱氨酸浓度五分位数2至五分位数5的T2DM的OR（95%CI）分别为1.05（0.92-1.21）、0.99（0.86-1.14）、0.90（0.78-1.05）和0.77（0.66-0.90）（趋势P<0.0001）。同型半胱氨酸浓度与T2DM患病率风险降低相关（同型半胱氨酸浓度每标准差增加，OR=0.88；95%CI：0.84-0.93）。观察到同型半胱氨酸浓度与饮酒状态对T2DM患病率风险有显著交互作用（交互作用P=0.03）。在不饮酒者中观察到血浆同型半胱氨酸浓度与T2DM患病率风险呈负相关，而在当前饮酒者中未观察到。
在中国中老年人群中，血浆同型半胱氨酸浓度与T2DM呈负相关。
