Azar Marwan M, Zhang Xuchen, Assi Roland, Hage Chadi, Wheat L Joseph, Malinis Maricar F
Yale School of Medicine, Department of Internal Medicine, Section of Infectious Diseases, New Haven, Connecticut, USA.
Yale School of Medicine, Department of Laboratory Medicine, New Haven, Connecticut, USA.
Med Mycol. 2018 Oct 1;56(7):896-899. doi: 10.1093/mmy/myx120.
We performed a retrospective analysis of histoplasmosis cases diagnosed at our institution in New Haven, Connecticut, from 2005 to 2015. Among 12 cases of active histoplasmosis, seven were immunosuppressed and five had human immunodeficiency virus (HIV). Eleven patients reported travel to potentially endemic areas at a median of 105 days prior to presentation; travel to the Caribbean was most common (n = 6). Median time to diagnosis from symptom onset and first Histoplasma antigen testing were 41 and 28 days, respectively. Consistent with reports from other non-endemic areas, our findings suggest that the epidemiology of histoplasmosis may differ in Connecticut, potentially contributing to delayed diagnoses.
我们对2005年至2015年在康涅狄格州纽黑文市我们机构诊断出的组织胞浆菌病病例进行了回顾性分析。在12例活动性组织胞浆菌病病例中，7例免疫功能低下，5例感染了人类免疫缺陷病毒（HIV）。11名患者报告在出现症状前中位时间为105天前往了可能的流行地区；前往加勒比地区最为常见（n = 6）。从症状出现到诊断以及首次进行组织胞浆菌抗原检测的中位时间分别为41天和28天。与其他非流行地区的报告一致，我们的研究结果表明，康涅狄格州的组织胞浆菌病流行病学可能有所不同，这可能导致诊断延迟。
