Hahn R G
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Acta Anaesthesiol Scand. 1989 Feb;33(2):146-51. doi: 10.1111/j.1399-6576.1989.tb02878.x.
The ethanol concentration in the expired breath (EB-ethanol), the volumetric fluid balance and the serum sodium concentration were measured in the course of 60 transurethral resections of the prostate in which the irrigating fluid was 1.5% glycine + 1% ethanol. Measurement of EB-ethanol indicated absorption of irrigant at a rate of more than 150 ml in 10 min, as measured volumetrically. There was a significant direct linear relationship between EB-ethanol and the cumulative volume of irrigant absorbed (R2 = 0.83); this correlation was stronger when the duration of absorption was taken into account (R2 = 0.90). EB-ethanol was inversely related to the overall change in the serum sodium concentration during the operation (R2 = 0.88). Symptoms that are recognized components of the TUR syndrome developed in 8 of the 13 patients absorbing more than 11 of irrigant, while the ethanol exerted no adverse effects. The results of the study indicate that 1% ethanol is a suitable marker for monitoring irrigant absorption by means of the expired breath test in routine transurethral surgery. At this concentration the sensitivity of the test is adequate for detecting absorption, while the ethanol is less toxic than the irrigant fluid itself.
在60例经尿道前列腺切除术过程中，测量了呼出气体中的乙醇浓度（EB - 乙醇）、液体容量平衡和血清钠浓度，这些手术中冲洗液为1.5%甘氨酸 + 1%乙醇。对EB - 乙醇的测量表明，按体积计算，冲洗液吸收速率超过150 ml/10 min。EB - 乙醇与吸收的冲洗液累积体积之间存在显著的直接线性关系（R2 = 0.83）；当考虑吸收持续时间时，这种相关性更强（R2 = 0.90）。EB - 乙醇与手术期间血清钠浓度的总体变化呈负相关（R2 = 0.88）。在13例吸收超过11的冲洗液的患者中，有8例出现了经尿道电切综合征的典型症状，而乙醇未产生不良影响。研究结果表明，1%乙醇是常规经尿道手术中通过呼出气体测试监测冲洗液吸收的合适标志物。在此浓度下，该测试的灵敏度足以检测吸收情况，同时乙醇的毒性低于冲洗液本身。
