Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China.
Nat Commun. 2017 Mar 14;8:14641. doi: 10.1038/ncomms14641.
Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C-C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via a C-H functionalization in good to excellent yield, and represents the first step towards a general transition metal catalysed synthesis of tetraarylmethanes.
四芳基甲烷衍生物在各种应用中很有价值，但通过现代 C-C 键形成反应难以获得。在这里，我们报告了一种用钯催化的芳基（杂芳基）甲烷和二芳基（杂芳基）甲烷与芳基氯化物的芳基化反应的直接方法。该反应能够通过 C-H 功能化引入各种芳基基团，以良好至优异的产率构建三芳基（杂芳基）甲烷，这是实现一般过渡金属催化合成四芳基甲烷的第一步。
