Lin Tingzhi, Qian Pengcheng, Wang Yan-En, Ou Mingjie, Jiang Long, Zhu Chen, Xu Yuchuan, Xiong Dan, Mao Jianyou
Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211800, P. R. China.
College of Science, Hebei Agricultural University, Baoding 071000, P. R. China.
Org Lett. 2021 Apr 16;23(8):3000-3003. doi: 10.1021/acs.orglett.1c00677. Epub 2021 Mar 29.
The first palladium-catalyzed direct arylation of 2-pyridylmethyl silanes with aryl bromides to generate a diverse array of aryl(2-pyridyl)-methyl silane derivatives has been developed. This protocol facilitates access to various kinds of heterocycle-containing silanes in good to excellent yields (40 examples, 66-97% yield) with good functional group tolerance. The scalability of this transformation is demonstrated.
已开发出首例钯催化的2-吡啶基甲基硅烷与芳基溴的直接芳基化反应，以生成一系列多样的芳基（2-吡啶基）甲基硅烷衍生物。该方法能够以良好至优异的产率（40个实例，产率66 - 97%）获得各种含杂环的硅烷，且具有良好的官能团耐受性。证明了这种转化反应的可扩展性。
