Ghoneim Sara, Ramos-Rodriguez Alvaro J, Vazquez de Lara Fernando, Bonomo Lauren
Saba University School of Medicine, The Bottom, Netherlands.
Icahn School of Medicine at Mount Sinai West, New York, NY, USA.
Case Rep Dermatol Med. 2017;2017:3280215. doi: 10.1155/2017/3280215. Epub 2017 Nov 2.
Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old African-American female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis. After failing conventional treatment regimens, the patient received a trial of ixekizumab with complete resolution of cutaneous lesions reported after 4 months and only 8 doses of the anti-IL-17 biologic agent.
线状银屑病是银屑病一种不常见的临床变异型，沿Blaschko线呈节段性表现。主要鉴别诊断为炎症性线状疣状表皮痣（ILVEN）。线状银屑病的治疗通常具有挑战性，文献报道对生物制剂反应不佳。我们报告一例25岁非裔美国女性病例，该患者沿Blaschko线出现无症状性角化过度丘疹，随后被诊断为线状银屑病。在传统治疗方案失败后，患者接受了ixekizumab试验性治疗，4个月后仅使用8剂这种抗IL-17生物制剂，皮肤病变即完全消退。
