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电休克疗法治疗氯氮平戒断谵妄

The Treatment of Clozapine-Withdrawal Delirium with Electroconvulsive Therapy.

作者信息

Modak Anish, Åhlin Arne

机构信息

Adult Mental Health Unit, The Canberra Hospital, ACT Health, GPO Box 825, Canberra, ACT 2601, Australia.

出版信息

Case Rep Psychiatry. 2017;2017:1783545. doi: 10.1155/2017/1783545. Epub 2017 Nov 2.

DOI:10.1155/2017/1783545
PMID:29230342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5688366/
Abstract

Clozapine, a commonly used atypical antipsychotic, can precipitate a severe withdrawal syndrome. In this report, we describe a case of delirium with catatonic features emerging after the immediate cessation of clozapine subsequent to concerns of developing neuroleptic malignant syndrome. After multiple treatments were found to be inefficacious, electroconvulsive therapy (ECT) was initiated, resulting in significant improvement. A literature search revealed six previous cases of clozapine-withdrawal syndromes of varied symptomatology treated with ECT. To our knowledge, the present case represents the first reported clozapine-withdrawal delirium treated successfully with ECT.

摘要

氯氮平是一种常用的非典型抗精神病药物，可引发严重的戒断综合征。在本报告中，我们描述了一例在因担心发生抗精神病药物恶性综合征而立即停用氯氮平后出现具有紧张症特征的谵妄病例。在发现多种治疗方法均无效后，启动了电休克治疗（ECT），结果病情显著改善。文献检索发现之前有6例使用ECT治疗的症状各异的氯氮平戒断综合征病例。据我们所知，本病例是首例报道的成功使用ECT治疗的氯氮平戒断性谵妄。