急性淋巴细胞白血病——手持镜变异型。一大组患者的分析。

Acute lymphoblastic leukemia--hand mirror variant. An analysis of a large group of patients.

作者信息

Schumacher H R, Champion J E, Thomas W J, Pitts L L, Stass S A

出版信息

Am J Hematol. 1979;7(1):11-7. doi: 10.1002/ajh.2830070103.

Abstract

One hundred and thirty-four initial bone marrows and 102 peripheral blood smears were evaluated for hand mirror cells (HMC) on pediatric patients with acute lymphoblastic leukemia (ALL). Twenty (15%) of the 134 patients were found to have greater than 5% HMC in their bone marrows. Only rarely were a few HMC noted in the peripheral blood. Survival did not appear to be related to the number of HMC in the bone marrow. Also, the median survival was not significantly greater in those HMC patients with greater than 40% HMC in their bone marrows when compared to the non-HMC group. From the available data in this study, it would appear that the number of HMC does not affect prognosis in the bone marrows of children with ALL. However, the prognostic significance of the HMC has not been clearly established in adults.

摘要

对134例急性淋巴细胞白血病（ALL）患儿的初始骨髓样本和102份外周血涂片进行了手镜细胞（HMC）评估。在134例患者中，有20例（15%）骨髓中的HMC超过5%。外周血中仅偶尔发现少量HMC。生存率似乎与骨髓中HMC的数量无关。此外，与非HMC组相比，骨髓中HMC超过40%的HMC患者的中位生存期并无显著延长。根据本研究的现有数据，HMC的数量似乎并不影响ALL患儿骨髓的预后。然而，HMC在成人中的预后意义尚未明确确立。