Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055, P. R. China.
Department of Physics and Materials Science, City University of Hong Kong , Tat Chee Avenue, Kowloon, Hong Kong 999077, P. R. China.
ACS Appl Mater Interfaces. 2018 Jan 10;10(1):1155-1163. doi: 10.1021/acsami.7b17117. Epub 2017 Dec 20.
One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (BiSe) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability. Cell experiments and hematological analyses demonstrate that the BiSe/PLLA membranes have excellent biocompatibility and low toxicity. PTT experiments performed in vivo with the BiSe/PLLA membrane covering the tumor and NIR irradiation produce local hyperthermia to ablate the tumor with high efficiency. Different from the traditional systematical and local injection techniques, this membrane-based PTT platform is promising in photothermal cancer therapy, especially suitable for the treatment of multiple solid tumors or skin cancers, and long-term prevention of cancer recurrence after surgery or PTT, while eliminating the health hazards of nanoagents.
光热癌症治疗面临的临床挑战之一是体内光热纳米制剂带来的健康风险。在此，描述了一种由二维材料基纳米纤维膜组成的光热治疗（PTT）平台，该平台作为在近红外（NIR）光照射下将热能传递至肿瘤的试剂。该光热膜是通过静电纺丝聚（L-乳酸）（PLLA）纳米纤维膜负载硒化铋（BiSe）纳米片制备的，具有非常高的光热转换效率和长期稳定性。细胞实验和血液分析表明，BiSe/PLLA 膜具有优异的生物相容性和低毒性。在肿瘤表面覆盖 BiSe/PLLA 膜并进行 NIR 照射的体内 PTT 实验可产生局部过热，从而高效消融肿瘤。与传统的系统性和局部注射技术不同，这种基于膜的 PTT 平台在光热癌症治疗中具有广阔的应用前景，特别适用于治疗多个实体瘤或皮肤癌，并可长期预防手术后或 PTT 后的癌症复发，同时消除纳米制剂的健康危害。
