Ploussard Guillaume
Division of Urology Saint Jean Languedoc Hospital, and Institut Universitaire du Cancer Oncopole, Toulouse, France.
Curr Opin Urol. 2018 Mar;28(2):153-158. doi: 10.1097/MOU.0000000000000470.
Despite the worldwile increasing use of robotic assistance for oncology surgery, no level 1 evidence-based benefit favoring robot-assisted radical prostatectomy (RARP) versus pure laparoscopic or open approaches has been demonstrated. We aimed to perform an update of the available evidence by evaluating most recent 2016-2017 data.
Population-based and prospective nonrandomized studies and one phase III randomised trial have been recently published. Early results from the phase III trial suggested that RARP led to similar early functional and oncologic outcomes compared with open radical prostatectomy. Shorter operative time, hospital stay, and lower complications rate and blood loss were reported in RARP group compared with open radical prostatectomy group. Population-based data did not demonstrate any benefit from one approach over another in terms of functional and oncologic outcomes. Robot assistance is predictive for improved potency recovery in organ-confined tumor in one large prospective trial. Main limitations, different among studies, were lack of randomization or single operator cohorts, short-term follow-up, and absence of confounding factors analysis.
Robotic assistance seems to confer better results than open radical prostatectomy procedures in terms of intra- and immediate postoperative parameters (operative time, blood loss and hospital stay). Clear advantages of one technique over another on robust functional or oncologic endpoints remain unproven.
尽管全球范围内肿瘤手术中机器人辅助的应用日益增加,但尚无一级循证医学证据表明机器人辅助根治性前列腺切除术(RARP)相对于单纯腹腔镜或开放手术具有优势。我们旨在通过评估2016 - 2017年的最新数据来更新现有证据。
最近发表了基于人群的前瞻性非随机研究和一项III期随机试验。III期试验的早期结果表明,与开放性根治性前列腺切除术相比,RARP导致相似的早期功能和肿瘤学结果。与开放性根治性前列腺切除术组相比,RARP组的手术时间更短、住院时间更短、并发症发生率更低且失血量更少。基于人群的数据在功能和肿瘤学结果方面未显示出一种方法优于另一种方法。在一项大型前瞻性试验中,机器人辅助可预测器官局限性肿瘤患者性功能恢复情况更好。研究中的主要局限性各不相同,包括缺乏随机分组或单一术者队列、短期随访以及未进行混杂因素分析。
在术中及术后即刻参数(手术时间、失血量和住院时间)方面,机器人辅助似乎比开放性根治性前列腺切除术效果更好。一种技术相对于另一种技术在强大的功能或肿瘤学终点方面的明显优势仍未得到证实。