McGinn Kaitlin A, Weigartz Katie, Lintner Alicia, Scalese Michael J, Kahn Steven A
1 Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, AL, USA.
2 Department of Surgery, University of South Alabama Medical Center, Mobile, AL, USA.
J Pharm Pract. 2019 Apr;32(2):163-166. doi: 10.1177/0897190017747143. Epub 2017 Dec 12.
Nebulized heparin has been proposed to improve pulmonary function in patients with inhalation injuries. The purpose of this study was to evaluate the impact of nebulized heparin with N-acetylcysteine (NAC) and albuterol on the duration of mechanical ventilation in burn patients.
This is a retrospective study evaluating mechanically ventilated adult patients admitted to a regional burn center with inhalation injury. Outcomes were compared between patients who were prescribed a combination of nebulized heparin with NAC and albuterol versus similar patients who did not.
A total of 48 patients met inclusion criteria (heparin n = 22; nonheparin n = 26). Patients in the nonheparin group had higher percentage of total body surface area (TBSA) burned (29.00 [5.75-51.88] vs 5.25 [0.50-13.25] %TBSA; P = .009), longer duration of mechanical ventilation (6.50 [2.75-17.00] vs 3.00 [1.00-8.25] days; P = .022), and longer intensive care unit length of stay (LOS) (3.00 [3.00-28.75] vs 5.50 days [2.00-11.25]; P = .033). Upon regression, use of heparin was the only variable associated with reducing the duration of mechanical ventilation ( P = .039).
Nebulized heparin in combination with NAC and albuterol was associated with a significant reduction in the duration of mechanical ventilation.
雾化吸入肝素已被提议用于改善吸入性损伤患者的肺功能。本研究的目的是评估雾化吸入肝素联合N - 乙酰半胱氨酸（NAC）和沙丁胺醇对烧伤患者机械通气时间的影响。
这是一项回顾性研究，评估入住某地区烧伤中心的成年机械通气吸入性损伤患者。将接受雾化吸入肝素联合NAC和沙丁胺醇治疗的患者与未接受该治疗的类似患者的结局进行比较。
共有48例患者符合纳入标准（肝素组n = 22；非肝素组n = 26）。非肝素组患者的烧伤总面积（TBSA）百分比更高（29.00 [5.75 - 51.88] vs 5.25 [0.50 - 13.25] %TBSA；P = .009），机械通气时间更长（6.50 [2.75 - 17.00] vs 3.00 [1.00 - 8.25]天；P = .022），重症监护病房住院时间（LOS）更长（3.00 [3.00 - 28.75] vs 5.50天[2.00 - 11.25]；P = .033）。经回归分析，使用肝素是与缩短机械通气时间相关的唯一变量（P = .039）。
雾化吸入肝素联合NAC和沙丁胺醇与机械通气时间显著缩短相关。
