Qi Guangzhao, Li Duolu, Zhang Xiaojian
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Drug Metab Pharmacokinet. 2018 Feb;33(1):55-60. doi: 10.1016/j.dmpk.2017.02.002. Epub 2017 Mar 6.
Interindividual and interethnic variability of drug responses could be attributed to the differences of genetic polymorphisms in the drug metabolizing enzymes and transporters genes among the populations. Here we reviewed the studies of genetic variations in Uyghur Chinese of fifteen CYP450 genes including CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP2J2, CYP2W1, CYP3A4, CYP3A5, CYP4A11, and CYP17A1, which totally covered 277 variants. We also collected the data of 277 variants covered in our study in two extensive population sequencing projects, the International HapMap Project (Hap-Map) and the 1000 Genomes Project and compared them with the data of Uyghur Chinese. The results suggested that remarkable differences of variants allele frequencies of CYP450 genes were existed among Uyghur Chinese and other world populations and drug doses should be adjusted clinically in Uyghur in contrast to Han Chinese and Caucasians.
个体间和种族间药物反应的变异性可能归因于不同人群中药物代谢酶和转运蛋白基因的遗传多态性差异。在此，我们回顾了对15个CYP450基因（包括CYP1A1、CYP1A2、CYP2A6、CYP2B6、CYP2C8、CYP2C9、CYP2C19、CYP2D6、CYP2E1、CYP2J2、CYP2W1、CYP3A4、CYP3A5、CYP4A11和CYP17A1）维吾尔族人群遗传变异的研究，这些研究共涵盖277个变异。我们还收集了我们研究中涵盖的277个变异在两个大规模人群测序项目——国际人类基因组单体型图计划（Hap-Map）和千人基因组计划中的数据，并将其与维吾尔族人群的数据进行比较。结果表明，维吾尔族人群与其他世界人群之间CYP450基因变异等位基因频率存在显著差异，与汉族和高加索人相比，维吾尔族人群的药物剂量在临床上应进行调整。
