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对于出生后第一年诊断出的重复肾输尿管囊肿,经尿道切开术比上极部分肾切除术更好吗?

Is transurethral incision better than upper pole partial nephrectomy for management of duplex system ureterocoele diagnosed in the first year of life?

作者信息

Hodhod Amr, Noureldin Yasser A, El-Sherbiny Mohamed

机构信息

Division of Urology, McGill University, Montréal, Québec, Canada.

Department of Urology, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.

出版信息

Arab J Urol. 2017 Sep 8;15(4):319-325. doi: 10.1016/j.aju.2017.08.001. eCollection 2017 Dec.

Abstract

OBJECTIVE

To compare the outcomes of transurethral incision (TUI) and upper pole partial nephrectomy (PN) in patients with duplex system ureterocoele (DSU).

PATIENTS AND METHODS

We retrospectively reviewed the medical charts of patients who presented with DSU in the first-year of life and were managed with either TUI or PN. Patients' demographics, ultrasonography examinations, voiding cystourethrogram studies, and dimercaptosuccinic acid scans were reviewed. Also, the postoperative vesico-ureteric reflux status and febrile urinary tract infection occurrences, and subsequent surgical interventions were identified. The outcomes for the DSU location (intravesical vs extravesical) were compared.

RESULTS

Between January 1995 and September 2015, 44 patients underwent TUI (31 patients) or PN (13). The TUI patients presented at a median age of 1.1 months and were followed-up for a median of 47.4 months, whilst those who underwent PN presented at a median age of 1.06 months and were followed-up for a median of 44.23 months. Postoperatively, in the TUI group, four of 15 units had improved renal function and 11 units had stable function. In the PN group, five of nine units had stable renal function and the remaining four had worsened function ( = 0.019). Furthermore, 15 of the 31 patients (48%) in the TUI group required second interventions compared with one of 13 patients in the PN group ( = 0.01). There was no significant difference between the outcomes of intravesical and extravesical DSUs after TUI and PN.

CONCLUSION

This study shows significant renal function preservation with TUI compared to PN. However, secondary surgical interventions were higher with TUI.

摘要

目的

比较双系统输尿管囊肿(DSU)患者经尿道切开术(TUI)和上极部分肾切除术(PN)的治疗效果。

患者与方法

我们回顾性分析了出生后第一年出现DSU并接受TUI或PN治疗的患者的病历。回顾了患者的人口统计学资料、超声检查、排尿性膀胱尿道造影研究和二巯基琥珀酸扫描结果。此外,还确定了术后膀胱输尿管反流状态、发热性尿路感染的发生情况以及后续的手术干预措施。比较了DSU位于膀胱内与膀胱外的治疗效果。

结果

1995年1月至2015年9月期间,44例患者接受了TUI(31例)或PN(13例)治疗。接受TUI的患者中位年龄为1.1个月,中位随访时间为47.4个月,而接受PN的患者中位年龄为1.06个月,中位随访时间为44.23个月。术后,TUI组15个单位中有4个肾功能改善,11个单位功能稳定。PN组9个单位中有5个肾功能稳定,其余4个单位功能恶化(P = 0.019)。此外,TUI组31例患者中有15例(48%)需要二次干预,而PN组13例患者中有1例(P = 0.01)。TUI和PN术后膀胱内和膀胱外DSU的治疗效果无显著差异。

结论

本研究表明,与PN相比,TUI能显著保留肾功能。然而,TUI的二次手术干预率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51db/5717465/91285f0e895f/gr1.jpg

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