• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

胆囊癌的分期、治疗及未来方法

Staging, Treatment, and Future Approaches of Gallbladder Carcinoma.

作者信息

Shukla Sanjeev Kumar, Singh Govind, Shahi K S, Pant Prabhat

机构信息

Multidisciplinary Research Unit, Government Medical College, Haldwani, Nainital, U.K., India.

Department of Biochemistry, Government Medical College, Haldwani, Nainital, Uttarakhand (U.K.), 263139, India.

出版信息

J Gastrointest Cancer. 2018 Mar;49(1):9-15. doi: 10.1007/s12029-017-0036-5.

DOI:10.1007/s12029-017-0036-5
PMID:29234972
Abstract

BACKGROUND

Gallbladder cancer is the most common malignant cancer of the bile ducts and third most common gastrointestinal malignant in the world for public health. Its relatively low incidence and confused symptoms result in advanced disease at the time of presentation, contributing to poor prognosis and reduced survival associated with this disease. The main function of the gallbladder is to store excreted bile acids from the liver in preparation for a meal. Its main risk factor is prolonged exposure to biliary calculations, although bacterial infections and other inflammatory conditions are associated. Chronic inflammatory bowel conditions are associated with gallbladder cancer. T stage translates to identifying residual disease at reoperation for incidental gallbladder cancer and residual disease negatively affects survival.

CONCLUSION

It is the most common cancer of gallbladder, gallbladder cancer remains a rare disease. Gallbladder cancer is a rare disease that can be accidentally diagnosed after cholecystectomy or accidentally, often with more advanced disease. The prognosis is generally extremely poor and improvements in surgical resection of this approach have to be re-evaluated, while the role of chemotherapy and radiotherapy remains controversial.

摘要

背景

胆囊癌是胆管最常见的恶性肿瘤,在全球公共卫生领域中是第三常见的胃肠道恶性肿瘤。其发病率相对较低且症状不明确,导致就诊时疾病已处于晚期,这使得该疾病的预后较差且生存率降低。胆囊的主要功能是储存肝脏排泄的胆汁酸以备进食时使用。其主要危险因素是长期接触胆结石,尽管细菌感染和其他炎症性疾病也与之相关。慢性炎症性肠病与胆囊癌有关。T分期用于确定意外胆囊癌再次手术时的残留疾病,而残留疾病会对生存率产生负面影响。

结论

胆囊癌是胆囊最常见的癌症,但它仍然是一种罕见疾病。胆囊癌是一种罕见疾病,可在胆囊切除术后偶然诊断,或者经常在疾病更为晚期时偶然发现。其预后通常极差,必须重新评估这种手术切除方法的改进情况,而化疗和放疗的作用仍存在争议。

相似文献

1
Staging, Treatment, and Future Approaches of Gallbladder Carcinoma.胆囊癌的分期、治疗及未来方法
J Gastrointest Cancer. 2018 Mar;49(1):9-15. doi: 10.1007/s12029-017-0036-5.
2
[Immediate radical re-resection of incidental T1b  gallbladder cancer and the problem of an adequate extent of resection (results of the German Registry "Incidental Gallbladder Cancer")].[意外发现的T1b期胆囊癌的即刻根治性再次切除术及切除范围是否足够的问题(德国“意外胆囊癌”登记研究结果)]
Zentralbl Chir. 2014 Dec;139 Suppl 2:e43-8. doi: 10.1055/s-0030-1262698. Epub 2011 Mar 1.
3
Surgical procedure determination based on tumor-node-metastasis staging of gallbladder cancer.基于胆囊癌肿瘤-淋巴结-转移分期的手术方案确定
World J Gastroenterol. 2015 Apr 21;21(15):4620-6. doi: 10.3748/wjg.v21.i15.4620.
4
Gallbladder cancer.胆囊癌
Am J Surg. 2008 Aug;196(2):252-64. doi: 10.1016/j.amjsurg.2007.11.011. Epub 2008 May 7.
5
Gallbladder carcinoma with biliary invasion: clinical analysis of the differences from nonbiliary invasion.伴有胆管侵犯的胆囊癌:与无胆管侵犯情况差异的临床分析
World J Surg. 2005 Jan;29(1):72-5. doi: 10.1007/s00268-004-7544-8.
6
Incidentally-discovered gallbladder cancer: When, why and which reoperation?偶然发现的胆囊癌:何时、为何及何种再次手术?
J Visc Surg. 2011 Apr;148(2):e77-84. doi: 10.1016/j.jviscsurg.2011.02.005. Epub 2011 Apr 8.
7
Systematic review of management of incidental gallbladder cancer after cholecystectomy.胆囊切除术后偶然发现的胆囊癌的处理:系统综述。
Br J Surg. 2019 Jan;106(1):32-45. doi: 10.1002/bjs.11035.
8
How Should Gallbladder Cancer Be Managed?胆囊癌应如何治疗?
Adv Surg. 2018 Sep;52(1):89-100. doi: 10.1016/j.yasu.2018.04.003. Epub 2018 Jun 25.
9
Carcinoma of the gallbladder.胆囊癌
Lancet Oncol. 2003 Mar;4(3):167-76. doi: 10.1016/s1470-2045(03)01021-0.
10
Gallbladder cancer: expert consensus statement.胆囊癌:专家共识声明。
HPB (Oxford). 2015 Aug;17(8):681-90. doi: 10.1111/hpb.12444.

引用本文的文献

1
Effects of radiotherapy, chemotherapy, and chemoradiotherapy on survival outcomes in patients with gallbladder carcinoma: a real population-based study.放疗、化疗及放化疗对胆囊癌患者生存结局的影响:一项基于真实人群的研究。
Transl Cancer Res. 2025 Jun 30;14(6):3627-3641. doi: 10.21037/tcr-2024-2543. Epub 2025 Jun 25.
2
Expression of inflammatory proteins STAT & NFĸB for phenotypic diagnosis of gall bladder cancer: A pilot study.用于胆囊癌表型诊断的炎症蛋白STAT和NFκB的表达:一项初步研究。
Indian J Med Res. 2025 Apr;161(4):414-419. doi: 10.25259/IJMR_1461_2024.
3
Screening of an individualized treatment strategy for an advanced gallbladder cancer using patient-derived tumor xenograft and organoid models.

本文引用的文献

1
Clinical epidemiological survey of gallbladder carcinoma in northwestern China, 2009-2013: 2379 cases in 17 centers.2009 - 2013年中国西北地区胆囊癌临床流行病学调查:17个中心的2379例病例
Chronic Dis Transl Med. 2017 Feb 22;3(1):60-66. doi: 10.1016/j.cdtm.2017.01.003. eCollection 2017 Mar 25.
2
A case report of the clear cell variant of gallbladder carcinoma.胆囊癌透明细胞变异型病例报告
Int J Surg Case Rep. 2017;32:36-39. doi: 10.1016/j.ijscr.2017.01.020. Epub 2017 Jan 12.
3
Healthy dietary patterns and incidence of biliary tract and gallbladder cancer in a prospective study of women and men.
使用患者来源的肿瘤异种移植模型和类器官模型筛选晚期胆囊癌的个体化治疗策略。
Front Oncol. 2022 Dec 14;12:1043479. doi: 10.3389/fonc.2022.1043479. eCollection 2022.
4
Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid lesions of gallbladder ≥ 1 cm.胆囊≥1cm 息肉样病变的超声造影诊断及鉴别诊断价值
BMC Gastroenterol. 2022 Jul 25;22(1):354. doi: 10.1186/s12876-022-02373-z.
5
Circulating miR-141 as a potential biomarker for diagnosis, prognosis and therapeutic targets in gallbladder cancer.循环 miR-141 作为胆囊癌诊断、预后和治疗靶点的潜在生物标志物。
Sci Rep. 2022 Jun 16;12(1):10072. doi: 10.1038/s41598-022-13430-8.
6
Oral microbiota in human systematic diseases.口腔微生物群与人类系统性疾病。
Int J Oral Sci. 2022 Mar 2;14(1):14. doi: 10.1038/s41368-022-00163-7.
7
The longitudinal change of circulating tumor cell during chemotherapy and its correlation with disease features, treatment response and survival profile of advanced gallbladder carcinoma.化疗期间循环肿瘤细胞的纵向变化及其与晚期胆囊癌疾病特征、治疗反应和生存情况的相关性。
Am J Transl Res. 2021 Dec 15;13(12):13590-13598. eCollection 2021.
8
Correlation of adenosine deaminase operating under nitro-oxidative stress with tumor and vascularization in patients with advanced gallbladder carcinoma.硝基氧化应激下腺苷脱氨酶与晚期胆囊癌患者肿瘤及血管生成的相关性
J Appl Biomed. 2019 Sep;17(3):175-183. doi: 10.32725/jab.2019.016. Epub 2019 Sep 17.
9
High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis.PSMC2的高表达通过调控GNG4促进胆囊癌发生并预示不良预后。
Oncogenesis. 2021 May 20;10(5):43. doi: 10.1038/s41389-021-00330-1.
10
Olaparib Treatment in a Patient with Advanced Gallbladder Cancer Harboring Mutation.奥拉帕利对一名携带特定突变的晚期胆囊癌患者的治疗
Onco Targets Ther. 2021 Apr 22;14:2815-2819. doi: 10.2147/OTT.S303594. eCollection 2021.
一项针对男性和女性的前瞻性研究中健康饮食模式与胆道和胆囊癌发病率的关系
Eur J Cancer. 2017 Jan;70:42-47. doi: 10.1016/j.ejca.2016.10.012. Epub 2016 Nov 18.
4
Burden of gallbladder cancer in Central and South America.中美洲和南美洲胆囊癌的负担。
Cancer Epidemiol. 2016 Sep;44 Suppl 1:S82-S89. doi: 10.1016/j.canep.2016.07.021.
5
Technical Aspects of Gallbladder Cancer Surgery.胆囊癌手术的技术方面
Surg Clin North Am. 2016 Apr;96(2):229-45. doi: 10.1016/j.suc.2015.12.007.
6
Gallbladder carcinoma: Prognostic factors and therapeutic options.胆囊癌:预后因素与治疗选择
World J Gastroenterol. 2015 Nov 21;21(43):12211-7. doi: 10.3748/wjg.v21.i43.12211.
7
Persistent Coughing as the First Symptom of Primary Mucinous Appendiceal Adenocarcinoma.持续性咳嗽作为原发性黏液性阑尾腺癌的首发症状
J Clin Med Res. 2015 Aug;7(8):649-52. doi: 10.14740/jocmr2192w. Epub 2015 Jun 9.
8
Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type?肺腺鳞癌的分子特征分析:混合型还是真正类型?
Oncotarget. 2015 Sep 15;6(27):23905-16. doi: 10.18632/oncotarget.4163.
9
Minimally invasive versus the conventional open surgical approach of a radical cholecystectomy for gallbladder cancer: a retrospective comparative study.微创与传统开放手术治疗胆囊癌的根治性胆囊切除术:一项回顾性比较研究。
HPB (Oxford). 2015 Jun;17(6):536-41. doi: 10.1111/hpb.12406. Epub 2015 Feb 28.
10
Microsatellite instability in gallbladder carcinoma.胆囊癌中的微卫星不稳定性
Virchows Arch. 2015 Apr;466(4):393-402. doi: 10.1007/s00428-015-1720-0. Epub 2015 Feb 14.