Zheng Yang, Bao Ming, Yao Ruwei, Qiu Lihua, Xu Xinfang
Key Laboratory of Organic Synthesis of Jiangsu Province; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Chem Commun (Camb). 2018 Jan 4;54(4):350-353. doi: 10.1039/c7cc08221e.
An unprecedented palladium-catalyzed novel carbene/alkyne metathesis cascade reaction of alkyne-tethered enynones is described. This reaction affords fused polyheterocycles in moderate to good yields. The transformation begins with Pd-catalyzed 5-exo-dig cyclization of the enynone to form the donor/donor metal carbene, which then undergoes metathesis with the alkyne followed by electrophilic aromatic substitution.
本文描述了一种前所未有的钯催化的炔基连接烯炔酮的新型卡宾/炔烃复分解串联反应。该反应以中等至良好的产率提供稠合多杂环化合物。该转化过程始于钯催化的烯炔酮的5-外环化反应，形成供体/供体金属卡宾，然后该卡宾与炔烃发生复分解反应，接着进行亲电芳香取代反应。
