Institute of Next Generation Matter Transformation, College of Chemical Engineering and College of Material Sciences Engineering, Huaqiao University, 668 Jimei Blvd, Xiamen, Fujian 361021, China.
Key Laboratory of Molecule Synthesis and Function Discovery (Fijian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
Org Lett. 2023 Mar 31;25(12):2113-2117. doi: 10.1021/acs.orglett.3c00539. Epub 2023 Mar 20.
Herein, we report a new method of synthesizing of 2-aminobenzofuran 3-enes via the formal C-S insertion reaction of alkyne-tethered diazo compounds. Metal carbene, as a kind of active synthetic intermediate, plays a very important role in organic synthesis. Through the carbene/alkyne metathesis strategy, a new donor carbene is produced in situ as a key intermediate, which has different reactions from the donor receptor carbene.
在此，我们报告了一种通过炔烃键合重氮化合物的形式 C-S 插入反应合成 2-氨基苯并呋喃 3-烯的新方法。金属卡宾作为一种活性合成中间体，在有机合成中起着非常重要的作用。通过卡宾/炔烃交叉复分解策略，原位生成新的给电子卡宾作为关键中间体，其与给体受体卡宾的反应不同。
