Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Org Biomol Chem. 2019 Feb 27;17(9):2326-2330. doi: 10.1039/c9ob00113a.
A copper-catalyzed selective cascade reaction of alkyne-tethered diazo compounds is reported for the direct and efficient construction of dihydrocyclohepta[b]indole skeletons under mild reaction conditions. A vinyl copper carbene is the key intermediate, which is generated in situ via carbene/alkyne metathesis (CAM) and terminated with the Buchner reaction.
本文报道了铜催化的炔丙基重氮化合物的选择性级联反应，在温和的反应条件下，可直接、高效地构建二氢环庚[b]吲哚骨架。乙烯基铜卡宾是关键的中间体，通过卡宾/炔烃交叉复分解（CAM）原位生成，并通过 Buchner 反应终止。
