Garcia Diego Paim Carvalho, Santos Clarissa, Nunes Cristiana Buzelin, Buzelin Marcelo Araújo, Petroianu Andy, Figueiredo Luiza Ohasi de, Motta Andreia Souto da, Gaspar Cristiane de Barros, Alberti Luiz Ronaldo
PhD, Associate Professor, Department of Surgery, Instituto de Ensino e Pesquisa da Santa Casa, Belo Horizonte-MG, Brazil. Intellectual and scientific content of the study, design the protocol, technical procedures, manuscript writing.
MD, Hospital Universitário São José, Belo Horizonte-MG, Brazil. Acquisition and interpretation of data, statistical analysis, design the protocol, technical procedures, macroscopic and histopathological examinations.
Acta Cir Bras. 2017 Nov;32(11):903-912. doi: 10.1590/s0102-865020170110000002.
To compare the effectiveness of light-weight polypropylene mesh coated with polymerized and purified bovine type I collagen (Surgidry HNB) in the treatment of abdominal wall defect and the degree of adhesion formation.
Two types of polypropylene mesh were implanted after creation of defect measuring 6.0cm X 5.5cm in the anterior abdominal wall of 32 male New Zealand breed rabbits, divided in two groups (n = 32): (1) light-weigh macroporous polypropylene, (2) type I polymerized and purified bovine collagen coated light-weigh macroporous polypropylene. These animals were further accessed for adhesions, histological evaluation of inflammation and wall's thickness.
The percentage of the area adhered in group 1 (62.31 ± 16.6) was higher compared to group 2 (22.19 ± 14.57) (p <0.05). There was an association between the percentage of the covered area by adhesions and the type of adhesion, toughness and the scores obtained by the adhesion score by correlation analysis (p <0.05). There was no difference between the groups in any variables in relation to the degree of inflammation.
The purified type I bovine collagen coated light-weigh polypropylene mesh showed to be effective in the repair of abdominal wall defects and reducing adhesion formation.
比较涂有聚合纯化牛I型胶原蛋白的轻质聚丙烯网片（Surgidry HNB）在治疗腹壁缺损中的有效性以及粘连形成程度。
在32只雄性新西兰兔的腹壁前部制造一个6.0cm×5.5cm的缺损后，植入两种类型的聚丙烯网片，分为两组（n = 32）：（1）轻质大孔聚丙烯，（2）涂有I型聚合纯化牛胶原蛋白的轻质大孔聚丙烯。对这些动物进一步评估粘连情况、炎症的组织学评估和腹壁厚度。
第1组（62.31±16.6）的粘连面积百分比高于第2组（22.19±14.57）（p<0.05）。通过相关性分析，粘连覆盖面积百分比与粘连类型、韧性以及粘连评分所获分数之间存在关联（p<0.05）。在炎症程度的任何变量方面，两组之间均无差异。
涂有纯化I型牛胶原蛋白的轻质聚丙烯网片在修复腹壁缺损和减少粘连形成方面显示出有效性。
