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急性缺血性小儿卒中的管理:机械取栓的延长时间窗?

Acute Ischemic Pediatric Stroke Management: An Extended Window for Mechanical Thrombectomy?

作者信息

Kulhari Ashish, Dorn Elizabeth, Pace Jonathan, Alambyan Vilakshan, Chen Stephanie, Wu Osmond C, Rizvi Macym, Hammond Anthony, Ramos-Estebanez Ciro

机构信息

Department of Neurology, Neurological Institute, University Hospitals, Cleveland, OH, United States.

Department of Neurological Surgery, Neurological Institute, University Hospitals, Cleveland, OH, United States.

出版信息

Front Neurol. 2017 Nov 29;8:634. doi: 10.3389/fneur.2017.00634. eCollection 2017.

DOI:10.3389/fneur.2017.00634
PMID:29238322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5712569/
Abstract

Ischemic stroke is a rare condition to afflict the pediatric population. Congenital cardiomyopathy represents one of several possible etiologies in children. We report a 9-year-old boy who developed right middle cerebral artery stroke secondary to primary restrictive cardiomyopathy. In the absence of pediatric guidelines, the child met adult criteria for mechanical thrombectomy given the small core infarct and large penumbra. The literature suggests children may benefit from mechanical thrombectomy in carefully selected cases. Our patient exemplifies specific circumstances in which acute stroke therapy with thrombolysis and thrombectomy may be safe.

摘要

缺血性中风是一种在儿科人群中较为罕见的病症。先天性心肌病是儿童中风的几种可能病因之一。我们报告了一名9岁男孩,他因原发性限制性心肌病继发右大脑中动脉中风。鉴于梗死核心小且半暗带大,在缺乏儿科指南的情况下,该患儿符合成人机械取栓标准。文献表明,在经过精心挑选的病例中,儿童可能从机械取栓中获益。我们的患者例证了在某些特定情况下,采用溶栓和取栓进行急性中风治疗可能是安全的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3f/5712569/cd0a36791085/fneur-08-00634-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3f/5712569/9dbc7b589f01/fneur-08-00634-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3f/5712569/cd0a36791085/fneur-08-00634-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3f/5712569/9dbc7b589f01/fneur-08-00634-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3f/5712569/cd0a36791085/fneur-08-00634-g002.jpg

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本文引用的文献

1
Endovascular Therapy in Pediatric Stroke: Utilization, Patient Characteristics, and Outcomes.小儿卒中的血管内治疗:应用情况、患者特征及预后
Pediatr Neurol. 2017 Apr;69:87-92.e2. doi: 10.1016/j.pediatrneurol.2017.01.013. Epub 2017 Jan 25.
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Guidelines for Urgent Management of Stroke in Children.
Pediatr Neurol. 2016 Mar;56:8-17. doi: 10.1016/j.pediatrneurol.2016.01.016. Epub 2016 Jan 21.
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Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.静脉注射阿替普酶用于急性缺血性脑卒中的纳入和排除标准的科学依据:美国心脏协会/美国卒中协会医疗保健专业人员的声明。
儿童缺血性脑卒中的血管内治疗:单中心经验及文献复习。
Interv Neuroradiol. 2021 Feb;27(1):16-24. doi: 10.1177/1591019920958827. Epub 2020 Sep 9.
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Stroke. 2015 Oct;46(10):3020-35. doi: 10.1161/STR.0000000000000074. Epub 2015 Jun 29.
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