Pediatric Endocrinology Division, Children's Hospital, University of Bonn, Bonn, Germany.
Department of Pediatrics and Adolescent Medicine, University of Cologne, Cologne, Germany.
J Diabetes Res. 2017;2017:8615769. doi: 10.1155/2017/8615769. Epub 2017 Nov 7.
In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control.
To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related.
Using a large multicentre database, longitudinal data from 1294 patients were analysed. Inclusion criteria: complete records of height and HbA1c from the age of seven to 16 years. Exclusion criteria: other significant chronic diseases and medications, T1DM duration less than three months, and initial BMI < 3rd or >97th percentile.
Growth velocity (GV) was impaired with a significant reduction of peak GV by 1.2 cm in boys. HbA1c increase during male puberty was lower except for a period of 1.5 years. The highest HbA1c increase in boys coincided with maximum growth spurt. In girls, the highest HbA1c increase was observed during late puberty. Even though there is impaired GV, both sexes reach a height at 16 years of age which corresponds to the background population height.
Worsening of metabolic control is sex-discordant and associated with gender-specific alterations of GV. However, the vast majority of boys and girls with T1DM seems to reach normal height at the age of 16 years.
在 1 型糖尿病中，青春期发育延迟和最终身高降低与代谢控制不充分有关。
评估 1 型糖尿病是否会影响青春期生长突增，以及青春期的代谢控制是否与性别有关。
使用大型多中心数据库，分析了 1294 名患者的纵向数据。纳入标准：7 至 16 岁时完整的身高和 HbA1c 记录。排除标准：其他重大慢性疾病和药物、1 型糖尿病病程少于 3 个月、初始 BMI<第 3 百分位数或>第 97 百分位数。
生长速度（GV）受损，男孩的峰值 GV 显著降低了 1.2cm。男性青春期期间的 HbA1c 升高较低，除了 1.5 年的时间。男孩的最高 HbA1c 升高与生长突增的最大值相吻合。在女孩中，最高的 HbA1c 升高发生在青春期后期。尽管 GV 受损，但男性和女性在 16 岁时的身高都达到了与背景人群身高相对应的高度。
代谢控制的恶化存在性别差异，与性别特异性的 GV 改变有关。然而，绝大多数患有 1 型糖尿病的男孩和女孩似乎在 16 岁时达到了正常身高。
