给予D-天冬氨酸可增加小鼠肝脏中D-天冬氨酸氧化酶的活性。
Administration of D-aspartate increases D-aspartate oxidase activity in mouse liver.
作者信息
Yamada R, Nagasaki H, Nagata Y, Wakabayashi Y, Iwashima A
机构信息
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
出版信息
Biochim Biophys Acta. 1989 Mar 24;990(3):325-8. doi: 10.1016/s0304-4165(89)80053-4.
Oral administration of D-aspartate to mice for 2 weeks by addition of the amino acid to drinking water produced a nearly 4-fold increase in liver D-aspartate oxidase (EC 1.4.3.1) activity, whereas no increase was induced by L-aspartate administered in the same way. Administration of D-aspartate also produced a small significant increase in the kidney enzyme activity, but L-aspartate administration increased the activity as well. The enzyme activity in the brain and muscle was not affected by administration of either D- or L-aspartate. Intraperitoneal administration of D-aspartate increased the enzyme activity only in the liver, and other compounds tested, including D-glutamate and D-alanine, could not replace D-aspartate. The results indicate a specific relationship between D-aspartate and D-aspartate oxidase and suggest that the amino acid is, in fact, a physiological substrate of the enzyme.
通过在饮用水中添加 D - 天冬氨酸给小鼠口服 2 周，肝脏 D - 天冬氨酸氧化酶（EC 1.4.3.1）活性增加了近 4 倍，而以同样方式给予 L - 天冬氨酸则未诱导活性增加。给予 D - 天冬氨酸也使肾脏酶活性有小幅显著增加，但给予 L - 天冬氨酸也会增加该活性。大脑和肌肉中的酶活性不受 D - 或 L - 天冬氨酸给药的影响。腹腔注射 D - 天冬氨酸仅增加肝脏中的酶活性，所测试的其他化合物，包括 D - 谷氨酸和 D - 丙氨酸，均不能替代 D - 天冬氨酸。结果表明 D - 天冬氨酸与 D - 天冬氨酸氧化酶之间存在特定关系，并表明该氨基酸实际上是该酶的生理底物。
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