Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):69-81. doi: 10.1002/psp4.12269. Epub 2017 Dec 14.
Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal development. New insights into the mechanisms of pregnancy-related disorders, such as preterm birth (PTB), may lead to the development of new therapeutic interventions and novel biomarkers.
妊娠涉及母体和胎儿之间的快速生理适应和复杂相互作用。新的分析技术提供了大量的基因组、蛋白质组和代谢组学数据。通过生物信息学、统计和系统药理学技术整合这些数据，可以提高我们对正常母体生理变化和胎儿发育机制的理解。对妊娠相关疾病（如早产）机制的新认识可能会导致新的治疗干预和新的生物标志物的发展。
