氧化还原中性氰基烷基化/环化烯烃 1,3-二羰基化合物与环酮肟酯：氰基烷基化二氢呋喃的获得。
Redox-Neutral Cyanoalkylation/Cyclization of Olefinic 1,3-Dicarbonyls with Cycloketone Oxime Esters: Access to Cyanoalkylated Dihydrofurans.
机构信息
Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter , Xi'an Jiaotong University , Xi'an 710049 , China.
出版信息
J Org Chem. 2018 Apr 6;83(7):4239-4249. doi: 10.1021/acs.joc.8b00271. Epub 2018 Mar 22.
PMID:29557652
Abstract
Metal-catalyzed cyanoalkylation/cyclization of olefinic 1,3-dicarbonyls with cycloketone oxime esters has been developed under redox-neutral conditions. This protocol provided a straightforward approach to diverse cyanoalkylated 2,3-dihydrofurans via a tandem ring-opening/addition/cyclization process.
摘要
金属催化的烯烃与环酮肟酯的氰烷基化/环化反应在氧化还原中性条件下得到了发展。该方案通过串联开环/加成/环化过程，为各种氰烷基化的 2,3-二氢呋喃提供了一种直接的方法。
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