Bowers M B, Swigar M E, Jatlow P I, Hoffman F J
Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
Biol Psychiatry. 1989 Mar 15;25(6):734-8. doi: 10.1016/0006-3223(89)90245-x.
Using either haloperidol or perphenazine in a fixed-dose protocol, plasma free homovanillic acid (HVA) and methoxyhydroxyphenethylglycol (MHPG) were decreased in 37 nonorganic psychotic inpatients at neuroleptic steady state (7-9 days) in comparison with pretreatment values. The data indicate that the magnitude of the decline in HVA and MHPG was associated with treatment response and not with neuroleptic plasma levels.
