治疗前血浆高香草酸可预测躁狂性精神病的抗精神病药物反应。

Pretreatment plasma HVA predicts neuroleptic response in manic psychosis.

作者信息

Mazure C M, Bowers M B

机构信息

Yale University School of Medicine, Department of Psychiatry, Yale New Haven Hospital, CT 06504, USA.

出版信息

J Affect Disord. 1998 Feb;48(1):83-6. doi: 10.1016/s0165-0327(97)00159-6.

DOI:10.1016/s0165-0327(97)00159-6

PMID:9495606

Abstract

Elevated pretreatment plasma free homovanillic acid (HVA) predicted acute response to neuroleptic treatment in patients with manic psychosis. These findings suggest that plasma HVA may be a useful predictor of a successful short-term response in manic as well as schizophrenic psychoses, and that elevated pre-synaptic dopaminergic release may play a role in more than one group of psychotic disorders.

摘要

治疗前血浆游离高香草酸（HVA）水平升高可预测躁狂性精神病患者对抗精神病药物治疗的急性反应。这些发现表明，血浆HVA可能是躁狂症和精神分裂症短期治疗成功的有用预测指标，并且突触前多巴胺能释放增加可能在不止一类精神障碍中起作用。